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Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
OBJECTIVE: To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold. METHODS: Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM). RESULTS: Contact allergy...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2002
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65540/ https://www.ncbi.nlm.nih.gov/pubmed/11860615 |
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author | Svensson, Åke Möller, Halvor Björkner, Bert Bruze, Magnus Leden, Ido Theander, Jan Ohlsson, Kjell Linder, Carina |
author_facet | Svensson, Åke Möller, Halvor Björkner, Bert Bruze, Magnus Leden, Ido Theander, Jan Ohlsson, Kjell Linder, Carina |
author_sort | Svensson, Åke |
collection | PubMed |
description | OBJECTIVE: To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold. METHODS: Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM). RESULTS: Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients. CONCLUSIONS: Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute adverse reactions the starting dose of GSTM should be lowered to 5 mg. Alternatively, patients should be patch-tested before gold therapy; in test-positive cases, 5 mg is recommended as the first dose. |
format | Text |
id | pubmed-65540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2002 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-655402002-02-19 Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines Svensson, Åke Möller, Halvor Björkner, Bert Bruze, Magnus Leden, Ido Theander, Jan Ohlsson, Kjell Linder, Carina BMC Dermatol Research Article OBJECTIVE: To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold. METHODS: Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM). RESULTS: Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients. CONCLUSIONS: Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute adverse reactions the starting dose of GSTM should be lowered to 5 mg. Alternatively, patients should be patch-tested before gold therapy; in test-positive cases, 5 mg is recommended as the first dose. BioMed Central 2002-02-01 /pmc/articles/PMC65540/ /pubmed/11860615 Text en Copyright © 2002 Svensson et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any purpose, provided this notice is preserved along with the article's original URL. |
spellingShingle | Research Article Svensson, Åke Möller, Halvor Björkner, Bert Bruze, Magnus Leden, Ido Theander, Jan Ohlsson, Kjell Linder, Carina Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines |
title | Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines |
title_full | Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines |
title_fullStr | Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines |
title_full_unstemmed | Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines |
title_short | Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines |
title_sort | rheumatoid arthritis, gold therapy, contact allergy and blood cytokines |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65540/ https://www.ncbi.nlm.nih.gov/pubmed/11860615 |
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