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Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines

OBJECTIVE: To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold. METHODS: Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM). RESULTS: Contact allergy...

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Autores principales: Svensson, Åke, Möller, Halvor, Björkner, Bert, Bruze, Magnus, Leden, Ido, Theander, Jan, Ohlsson, Kjell, Linder, Carina
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65540/
https://www.ncbi.nlm.nih.gov/pubmed/11860615
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author Svensson, Åke
Möller, Halvor
Björkner, Bert
Bruze, Magnus
Leden, Ido
Theander, Jan
Ohlsson, Kjell
Linder, Carina
author_facet Svensson, Åke
Möller, Halvor
Björkner, Bert
Bruze, Magnus
Leden, Ido
Theander, Jan
Ohlsson, Kjell
Linder, Carina
author_sort Svensson, Åke
collection PubMed
description OBJECTIVE: To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold. METHODS: Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM). RESULTS: Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients. CONCLUSIONS: Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute adverse reactions the starting dose of GSTM should be lowered to 5 mg. Alternatively, patients should be patch-tested before gold therapy; in test-positive cases, 5 mg is recommended as the first dose.
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spelling pubmed-655402002-02-19 Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines Svensson, Åke Möller, Halvor Björkner, Bert Bruze, Magnus Leden, Ido Theander, Jan Ohlsson, Kjell Linder, Carina BMC Dermatol Research Article OBJECTIVE: To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold. METHODS: Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM). RESULTS: Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients. CONCLUSIONS: Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute adverse reactions the starting dose of GSTM should be lowered to 5 mg. Alternatively, patients should be patch-tested before gold therapy; in test-positive cases, 5 mg is recommended as the first dose. BioMed Central 2002-02-01 /pmc/articles/PMC65540/ /pubmed/11860615 Text en Copyright © 2002 Svensson et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Research Article
Svensson, Åke
Möller, Halvor
Björkner, Bert
Bruze, Magnus
Leden, Ido
Theander, Jan
Ohlsson, Kjell
Linder, Carina
Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
title Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
title_full Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
title_fullStr Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
title_full_unstemmed Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
title_short Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
title_sort rheumatoid arthritis, gold therapy, contact allergy and blood cytokines
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65540/
https://www.ncbi.nlm.nih.gov/pubmed/11860615
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