The role of Na(v)1.7 in human nociceptors: insights from human induced pluripotent stem cell–derived sensory neurons of erythromelalgia patients

The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (Na(V)) 1.7. Still, recent studies targeting Na(V)1.7 in clinical trials have provided conflicting results. Here, we differentiated induced pluripotent stem cells from IEM patient...

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Detalles Bibliográficos
Autores principales: Meents, Jannis E., Bressan, Elisangela, Sontag, Stephanie, Foerster, Alec, Hautvast, Petra, Rösseler, Corinna, Hampl, Martin, Schüler, Herdit, Goetzke, Roman, Le, Thi Kim Chi, Kleggetveit, Inge Petter, Le Cann, Kim, Kerth, Clara, Rush, Anthony M., Rogers, Marc, Kohl, Zacharias, Schmelz, Martin, Wagner, Wolfgang, Jørum, Ellen, Namer, Barbara, Winner, Beate, Zenke, Martin, Lampert, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554007/
https://www.ncbi.nlm.nih.gov/pubmed/30720580
http://dx.doi.org/10.1097/j.pain.0000000000001511

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