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Decoding type I and III interferon signalling during viral infection
Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554024/ https://www.ncbi.nlm.nih.gov/pubmed/30936491 http://dx.doi.org/10.1038/s41564-019-0421-x |
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author | Mesev, Emily V. LeDesma, Robert A. Ploss, Alexander |
author_facet | Mesev, Emily V. LeDesma, Robert A. Ploss, Alexander |
author_sort | Mesev, Emily V. |
collection | PubMed |
description | Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral defences. Next, we explore some of the ways viruses can interfere with, or circumvent, these defences. Lastly, we address the largely under-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of research into IFN signalling complexity and viral evasion across species. |
format | Online Article Text |
id | pubmed-6554024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-65540242019-06-06 Decoding type I and III interferon signalling during viral infection Mesev, Emily V. LeDesma, Robert A. Ploss, Alexander Nat Microbiol Review Article Interferon (IFN)-mediated antiviral responses are central to host defence against viral infection. Despite the existence of at least 20 IFNs, there are only three known cell surface receptors. IFN signalling and viral evasion mechanisms form an immensely complex network that differs across species. In this Review, we begin by highlighting some of the advances that have been made towards understanding the complexity of differential IFN signalling inputs and outputs that contribute to antiviral defences. Next, we explore some of the ways viruses can interfere with, or circumvent, these defences. Lastly, we address the largely under-reviewed impact of IFN signalling on host tropism, and we offer perspectives on the future of research into IFN signalling complexity and viral evasion across species. Nature Publishing Group UK 2019-04-01 2019 /pmc/articles/PMC6554024/ /pubmed/30936491 http://dx.doi.org/10.1038/s41564-019-0421-x Text en © The Author(s), under exclusive licence to Springer Nature Limited 2019 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Article Mesev, Emily V. LeDesma, Robert A. Ploss, Alexander Decoding type I and III interferon signalling during viral infection |
title | Decoding type I and III interferon signalling during viral infection |
title_full | Decoding type I and III interferon signalling during viral infection |
title_fullStr | Decoding type I and III interferon signalling during viral infection |
title_full_unstemmed | Decoding type I and III interferon signalling during viral infection |
title_short | Decoding type I and III interferon signalling during viral infection |
title_sort | decoding type i and iii interferon signalling during viral infection |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554024/ https://www.ncbi.nlm.nih.gov/pubmed/30936491 http://dx.doi.org/10.1038/s41564-019-0421-x |
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