Exonuclease Requirements for Mammalian Ribosomal RNA Biogenesis and Surveillance

Ribosomal RNA (rRNA) biogenesis is a multistep process requiring several nuclear and cytoplasmic exonucleases. The exact processing steps for mammalian 5.8S rRNA remain obscure. Here, using loss-of-function approaches in mouse embryonic stem cells and deep sequencing of rRNA intermediates, we invest...

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Detalles Bibliográficos
Autores principales: Pirouz, Mehdi, Munafò, Marzia, Ebrahimi, Aref G., Choe, Junho, Gregory, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554070/
https://www.ncbi.nlm.nih.gov/pubmed/31160785
http://dx.doi.org/10.1038/s41594-019-0234-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554070/
https://www.ncbi.nlm.nih.gov/pubmed/31160785
http://dx.doi.org/10.1038/s41594-019-0234-x

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