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Complex Lower Extremity Wound in the Complex Host: Results From a Multicenter Registry

BACKGROUND: The complex diabetic lower extremity wound has not been well studied. There are a variety of new technologies now being applied with a paucity of evidence in evaluating their outcomes. The aim of this study is to describe clinical outcomes in the complex lower extremity wound in the como...

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Autores principales: Kim, Paul J., Attinger, Christopher E., Orgill, Dennis, Galiano, Robert D., Steinberg, John S., Evans, Karen K., Lavery, Lawrence A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554184/
https://www.ncbi.nlm.nih.gov/pubmed/31321165
http://dx.doi.org/10.1097/GOX.0000000000002129
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author Kim, Paul J.
Attinger, Christopher E.
Orgill, Dennis
Galiano, Robert D.
Steinberg, John S.
Evans, Karen K.
Lavery, Lawrence A.
author_facet Kim, Paul J.
Attinger, Christopher E.
Orgill, Dennis
Galiano, Robert D.
Steinberg, John S.
Evans, Karen K.
Lavery, Lawrence A.
author_sort Kim, Paul J.
collection PubMed
description BACKGROUND: The complex diabetic lower extremity wound has not been well studied. There are a variety of new technologies now being applied with a paucity of evidence in evaluating their outcomes. The aim of this study is to describe clinical outcomes in the complex lower extremity wound in the comorbid host. We hypothesized that treatment choice would have minimal impact on healing outcomes in this compromised population. METHODS: A multicenter retrospective registry of patients with diabetes and lower extremity wounds was created to compare treatment modalities of collagen–glycosaminoglycan scaffold, negative-pressure wound therapy, local tissue flap, and free tissue transfer. Statistical analyses included descriptive, proportional comparisons and Cox regression. RESULTS: There were no statistical differences in age, hemoglobin A1c, or body mass index between groups. Study patients had a history of amputation (40.5%), peripheral vascular disease (54.6%), peripheral neuropathy (64.8%), end-stage renal disease (13.9%), renal/hepatic disease (40.4%), and hypertension (85%). The most common wound etiologies were surgical dehiscence (69%), diabetic neuropathic wounds (39%), and ischemic wounds (28%), most commonly located on the foot or at a prior amputation site (30%). Mean wound area was 57.9 cm(2) and almost half with exposed bone. There were no statistical differences between treatment groups in proportion or time to healing, recurrence, or time to return to baseline function. CONCLUSIONS: Commonly used treatment modalities employed for this population of patients resulted in similar outcomes. This is the first study to describe the complex diabetic lower extremity wound in a complex host.
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spelling pubmed-65541842019-07-18 Complex Lower Extremity Wound in the Complex Host: Results From a Multicenter Registry Kim, Paul J. Attinger, Christopher E. Orgill, Dennis Galiano, Robert D. Steinberg, John S. Evans, Karen K. Lavery, Lawrence A. Plast Reconstr Surg Glob Open Original Article BACKGROUND: The complex diabetic lower extremity wound has not been well studied. There are a variety of new technologies now being applied with a paucity of evidence in evaluating their outcomes. The aim of this study is to describe clinical outcomes in the complex lower extremity wound in the comorbid host. We hypothesized that treatment choice would have minimal impact on healing outcomes in this compromised population. METHODS: A multicenter retrospective registry of patients with diabetes and lower extremity wounds was created to compare treatment modalities of collagen–glycosaminoglycan scaffold, negative-pressure wound therapy, local tissue flap, and free tissue transfer. Statistical analyses included descriptive, proportional comparisons and Cox regression. RESULTS: There were no statistical differences in age, hemoglobin A1c, or body mass index between groups. Study patients had a history of amputation (40.5%), peripheral vascular disease (54.6%), peripheral neuropathy (64.8%), end-stage renal disease (13.9%), renal/hepatic disease (40.4%), and hypertension (85%). The most common wound etiologies were surgical dehiscence (69%), diabetic neuropathic wounds (39%), and ischemic wounds (28%), most commonly located on the foot or at a prior amputation site (30%). Mean wound area was 57.9 cm(2) and almost half with exposed bone. There were no statistical differences between treatment groups in proportion or time to healing, recurrence, or time to return to baseline function. CONCLUSIONS: Commonly used treatment modalities employed for this population of patients resulted in similar outcomes. This is the first study to describe the complex diabetic lower extremity wound in a complex host. Wolters Kluwer Health 2019-04-11 /pmc/articles/PMC6554184/ /pubmed/31321165 http://dx.doi.org/10.1097/GOX.0000000000002129 Text en Copyright © 2019 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Article
Kim, Paul J.
Attinger, Christopher E.
Orgill, Dennis
Galiano, Robert D.
Steinberg, John S.
Evans, Karen K.
Lavery, Lawrence A.
Complex Lower Extremity Wound in the Complex Host: Results From a Multicenter Registry
title Complex Lower Extremity Wound in the Complex Host: Results From a Multicenter Registry
title_full Complex Lower Extremity Wound in the Complex Host: Results From a Multicenter Registry
title_fullStr Complex Lower Extremity Wound in the Complex Host: Results From a Multicenter Registry
title_full_unstemmed Complex Lower Extremity Wound in the Complex Host: Results From a Multicenter Registry
title_short Complex Lower Extremity Wound in the Complex Host: Results From a Multicenter Registry
title_sort complex lower extremity wound in the complex host: results from a multicenter registry
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554184/
https://www.ncbi.nlm.nih.gov/pubmed/31321165
http://dx.doi.org/10.1097/GOX.0000000000002129
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