LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression

LncRNA PACER is a chondrocyte inflammation-associated long non-coding RNA (lncRNA), and chondrocyte inflammation is involved in osteoarthritis (OA). We observed that plasma PACER was down-regulated, while plasma HOTAIR was up-regulated in OA patients. Altered plasma levels of PACER and HOTAIR distin...

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Autores principales: Jiang, Mingwei, Liu, Jie, Luo, Tao, Chen, Qiu, Lu, Ming, Meng, Deqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554214/
https://www.ncbi.nlm.nih.gov/pubmed/31113870
http://dx.doi.org/10.1042/BSR20190404
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author Jiang, Mingwei
Liu, Jie
Luo, Tao
Chen, Qiu
Lu, Ming
Meng, Deqiang
author_facet Jiang, Mingwei
Liu, Jie
Luo, Tao
Chen, Qiu
Lu, Ming
Meng, Deqiang
author_sort Jiang, Mingwei
collection PubMed
description LncRNA PACER is a chondrocyte inflammation-associated long non-coding RNA (lncRNA), and chondrocyte inflammation is involved in osteoarthritis (OA). We observed that plasma PACER was down-regulated, while plasma HOTAIR was up-regulated in OA patients. Altered plasma levels of PACER and HOTAIR distinguished OA patients from healthy controls. PACER and HOTAIR were inversely correlated in both OA patients and healthy controls. PACER overexpression mediated the down-regulation of HOTAIR, while HOTAIR overexpression did not significantly affect PACER. PACER overexpression led to inhibited, while HOTAIR overexpression led to promoted apoptosis of chondrocyte. HOTAIR overexpression attenuated the effects of PACER overexpression. Therefore, lncRNA PACER is down-regulated in OA and regulates chondrocyte apoptosis by down-regulating lncRNA HOTAIR.
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spelling pubmed-65542142019-06-19 LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression Jiang, Mingwei Liu, Jie Luo, Tao Chen, Qiu Lu, Ming Meng, Deqiang Biosci Rep Research Articles LncRNA PACER is a chondrocyte inflammation-associated long non-coding RNA (lncRNA), and chondrocyte inflammation is involved in osteoarthritis (OA). We observed that plasma PACER was down-regulated, while plasma HOTAIR was up-regulated in OA patients. Altered plasma levels of PACER and HOTAIR distinguished OA patients from healthy controls. PACER and HOTAIR were inversely correlated in both OA patients and healthy controls. PACER overexpression mediated the down-regulation of HOTAIR, while HOTAIR overexpression did not significantly affect PACER. PACER overexpression led to inhibited, while HOTAIR overexpression led to promoted apoptosis of chondrocyte. HOTAIR overexpression attenuated the effects of PACER overexpression. Therefore, lncRNA PACER is down-regulated in OA and regulates chondrocyte apoptosis by down-regulating lncRNA HOTAIR. Portland Press Ltd. 2019-06-07 /pmc/articles/PMC6554214/ /pubmed/31113870 http://dx.doi.org/10.1042/BSR20190404 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Jiang, Mingwei
Liu, Jie
Luo, Tao
Chen, Qiu
Lu, Ming
Meng, Deqiang
LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression
title LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression
title_full LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression
title_fullStr LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression
title_full_unstemmed LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression
title_short LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression
title_sort lncrna pacer is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncrna hotair expression
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554214/
https://www.ncbi.nlm.nih.gov/pubmed/31113870
http://dx.doi.org/10.1042/BSR20190404
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