Developing a codon optimization method for improved expression of recombinant proteins in actinobacteria

Codon optimization by synonymous substitution is widely used for recombinant protein expression. Recent studies have investigated sequence features for codon optimization based on large-scale expression analyses. However, these studies have been limited to common host organisms such as Escherichia c...

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Detalles Bibliográficos
Autores principales: Saito, Yutaka, Kitagawa, Wataru, Kumagai, Toshitaka, Tajima, Naoyuki, Nishimiya, Yoshiyuki, Tamano, Koichi, Yasutake, Yoshiaki, Tamura, Tomohiro, Kameda, Tomoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554278/
https://www.ncbi.nlm.nih.gov/pubmed/31171855
http://dx.doi.org/10.1038/s41598-019-44500-z

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