Gene expression dysregulation domains are not a specific feature of Down syndrome

Down syndrome (DS), trisomy of human chromosome 21 (Hsa21), results in a broad range of phenotypes. A recent study reported that DS cells show genome-wide transcriptional changes in which up- or down-regulated genes are clustered in gene expression dysregulation domains (GEDDs). GEDDs were also repo...

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Detalles Bibliográficos
Autores principales: Ahlfors, Helena, Anyanwu, Nneka, Pakanavicius, Edvinas, Dinischiotu, Natalia, Lana-Elola, Eva, Watson-Scales, Sheona, Tosh, Justin, Wiseman, Frances, Briscoe, James, Page, Karen, Fisher, Elizabeth M. C., Tybulewicz, Victor L. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554309/
https://www.ncbi.nlm.nih.gov/pubmed/31171815
http://dx.doi.org/10.1038/s41467-019-10129-9

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