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Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2
Lack or excess expression of the surface ectoderm-expressed transcription factor Grainyhead-like2 (Grhl2), each prevent spinal neural tube closure. Here we investigate the causative mechanisms and find reciprocal dysregulation of epithelial genes, cell junction components and actomyosin properties i...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554357/ https://www.ncbi.nlm.nih.gov/pubmed/31171776 http://dx.doi.org/10.1038/s41467-019-10164-6 |