Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats

Endogenous fibroblast growth factor 20 (FGF20) supports maintenance of dopaminergic neurones within the nigrostriatal pathway. Moreover, direct intracerebral infusion of FGF20 protects against nigrostriatal tract loss in the 6-hydroxydopamine lesion rat model of Parkinson’s disease. Increasing endog...

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Detalles Bibliográficos
Autores principales: Fletcher, Edward J. R., Jamieson, Aran D., Williams, Gareth, Doherty, Patrick, Duty, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554393/
https://www.ncbi.nlm.nih.gov/pubmed/31171821
http://dx.doi.org/10.1038/s41598-019-44803-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554393/
https://www.ncbi.nlm.nih.gov/pubmed/31171821
http://dx.doi.org/10.1038/s41598-019-44803-1

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