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Targeted repositioning identifies drugs that increase fibroblast growth factor 20 production and protect against 6-hydroxydopamine-induced nigral cell loss in rats
Endogenous fibroblast growth factor 20 (FGF20) supports maintenance of dopaminergic neurones within the nigrostriatal pathway. Moreover, direct intracerebral infusion of FGF20 protects against nigrostriatal tract loss in the 6-hydroxydopamine lesion rat model of Parkinson’s disease. Increasing endog...
Autores principales: | Fletcher, Edward J. R., Jamieson, Aran D., Williams, Gareth, Doherty, Patrick, Duty, Susan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554393/ https://www.ncbi.nlm.nih.gov/pubmed/31171821 http://dx.doi.org/10.1038/s41598-019-44803-1 |
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