The Reversal of Immune Exclusion Mediated by Tadalafil and an Anti-tumor Vaccine Also Induces PDL1 Upregulation in Recurrent Head and Neck Squamous Cell Carcinoma: Interim Analysis of a Phase I Clinical Trial

Myeloid Derived suppressor cells (MDSCs) play a key role in the progression and recurrence of human malignancies and in restraining the efficacy of adjuvant therapies. We have previously shown that Tadalafil lowers MDSCs and regulatory T cells (Treg) in the blood and in the tumor, primes a tumor spe...

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Detalles Bibliográficos
Autores principales: Weed, Donald T., Zilio, Serena, Reis, Isildinha M., Sargi, Zoukaa, Abouyared, Marianne, Gomez-Fernandez, Carmen R., Civantos, Francisco J., Rodriguez, Carla P., Serafini, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554471/
https://www.ncbi.nlm.nih.gov/pubmed/31214178
http://dx.doi.org/10.3389/fimmu.2019.01206

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