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A threshold delay model of HIV infection of newborn infants through breastfeeding
The breast milk of HIV infected women contains HIV virus particles, therefore children can become infected through breastfeeding. We develop a mathematical epidemiological model of HIV infection in infants, infected children and infected women that represents infection of an infant/child as a series...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554533/ https://www.ncbi.nlm.nih.gov/pubmed/31194190 http://dx.doi.org/10.1016/j.idm.2019.05.001 |
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author | Teslya, Alexandra Qesmi, Redouane Wu, Jianhong Heffernan, Jane M. |
author_facet | Teslya, Alexandra Qesmi, Redouane Wu, Jianhong Heffernan, Jane M. |
author_sort | Teslya, Alexandra |
collection | PubMed |
description | The breast milk of HIV infected women contains HIV virus particles, therefore children can become infected through breastfeeding. We develop a mathematical epidemiological model of HIV infection in infants, infected children and infected women that represents infection of an infant/child as a series of exposures, by incorporating within-host virus dynamics in the individuals exposed to the virus through breastfeeding. We show that repeated exposures of the infant/child via breastfeeding can cause bi-stability dynamics and, subsequently, infection persistence even when the epidemiological basic reproduction number [Formula: see text] is less than unity. This feature of the model, due to a backward bifurcation, gives new insight into the control mechanisms of HIV disease through breastfeeding. |
format | Online Article Text |
id | pubmed-6554533 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-65545332019-06-10 A threshold delay model of HIV infection of newborn infants through breastfeeding Teslya, Alexandra Qesmi, Redouane Wu, Jianhong Heffernan, Jane M. Infect Dis Model Mathematics for Public Health--in honor of Karl Hadeler; Edited by Dr. Julien Arino, Dr. Fred Brauer, Dr. Mirjam Kretzschmar, Dr. Jianhong Wu The breast milk of HIV infected women contains HIV virus particles, therefore children can become infected through breastfeeding. We develop a mathematical epidemiological model of HIV infection in infants, infected children and infected women that represents infection of an infant/child as a series of exposures, by incorporating within-host virus dynamics in the individuals exposed to the virus through breastfeeding. We show that repeated exposures of the infant/child via breastfeeding can cause bi-stability dynamics and, subsequently, infection persistence even when the epidemiological basic reproduction number [Formula: see text] is less than unity. This feature of the model, due to a backward bifurcation, gives new insight into the control mechanisms of HIV disease through breastfeeding. KeAi Publishing 2019-05-16 /pmc/articles/PMC6554533/ /pubmed/31194190 http://dx.doi.org/10.1016/j.idm.2019.05.001 Text en © 2019 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Mathematics for Public Health--in honor of Karl Hadeler; Edited by Dr. Julien Arino, Dr. Fred Brauer, Dr. Mirjam Kretzschmar, Dr. Jianhong Wu Teslya, Alexandra Qesmi, Redouane Wu, Jianhong Heffernan, Jane M. A threshold delay model of HIV infection of newborn infants through breastfeeding |
title | A threshold delay model of HIV infection of newborn infants through breastfeeding |
title_full | A threshold delay model of HIV infection of newborn infants through breastfeeding |
title_fullStr | A threshold delay model of HIV infection of newborn infants through breastfeeding |
title_full_unstemmed | A threshold delay model of HIV infection of newborn infants through breastfeeding |
title_short | A threshold delay model of HIV infection of newborn infants through breastfeeding |
title_sort | threshold delay model of hiv infection of newborn infants through breastfeeding |
topic | Mathematics for Public Health--in honor of Karl Hadeler; Edited by Dr. Julien Arino, Dr. Fred Brauer, Dr. Mirjam Kretzschmar, Dr. Jianhong Wu |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554533/ https://www.ncbi.nlm.nih.gov/pubmed/31194190 http://dx.doi.org/10.1016/j.idm.2019.05.001 |
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