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Inflammasomes in neuroinflammatory and neurodegenerative diseases
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host‐derive...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554670/ https://www.ncbi.nlm.nih.gov/pubmed/31015277 http://dx.doi.org/10.15252/emmm.201810248 |
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author | Voet, Sofie Srinivasan, Sahana Lamkanfi, Mohamed van Loo, Geert |
author_facet | Voet, Sofie Srinivasan, Sahana Lamkanfi, Mohamed van Loo, Geert |
author_sort | Voet, Sofie |
collection | PubMed |
description | Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host‐derived danger signals. Upon activation, they induce an innate immune response by secreting the inflammatory cytokines interleukin (IL)‐1β and IL‐18, and additionally by inducing pyroptosis, a lytic cell death mode that releases additional inflammatory mediators. Microglia are the prominent innate immune cells in the brain for inflammasome activation. However, additional CNS‐resident cell types including astrocytes and neurons, as well as infiltrating myeloid cells from the periphery, express and activate inflammasomes. In this review, we will discuss current understanding of the role of inflammasomes in common degenerative diseases of the brain and highlight inflammasome‐targeted strategies that may potentially treat these diseases. |
format | Online Article Text |
id | pubmed-6554670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65546702019-06-10 Inflammasomes in neuroinflammatory and neurodegenerative diseases Voet, Sofie Srinivasan, Sahana Lamkanfi, Mohamed van Loo, Geert EMBO Mol Med Review Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate inflammasomes. Inflammasomes function as intracellular sensors of both microbial pathogens and foreign as well as host‐derived danger signals. Upon activation, they induce an innate immune response by secreting the inflammatory cytokines interleukin (IL)‐1β and IL‐18, and additionally by inducing pyroptosis, a lytic cell death mode that releases additional inflammatory mediators. Microglia are the prominent innate immune cells in the brain for inflammasome activation. However, additional CNS‐resident cell types including astrocytes and neurons, as well as infiltrating myeloid cells from the periphery, express and activate inflammasomes. In this review, we will discuss current understanding of the role of inflammasomes in common degenerative diseases of the brain and highlight inflammasome‐targeted strategies that may potentially treat these diseases. John Wiley and Sons Inc. 2019-04-23 2019-06 /pmc/articles/PMC6554670/ /pubmed/31015277 http://dx.doi.org/10.15252/emmm.201810248 Text en © 2019 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Voet, Sofie Srinivasan, Sahana Lamkanfi, Mohamed van Loo, Geert Inflammasomes in neuroinflammatory and neurodegenerative diseases |
title | Inflammasomes in neuroinflammatory and neurodegenerative diseases |
title_full | Inflammasomes in neuroinflammatory and neurodegenerative diseases |
title_fullStr | Inflammasomes in neuroinflammatory and neurodegenerative diseases |
title_full_unstemmed | Inflammasomes in neuroinflammatory and neurodegenerative diseases |
title_short | Inflammasomes in neuroinflammatory and neurodegenerative diseases |
title_sort | inflammasomes in neuroinflammatory and neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554670/ https://www.ncbi.nlm.nih.gov/pubmed/31015277 http://dx.doi.org/10.15252/emmm.201810248 |
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