Cargando…
OR12-3 Mice with MC4R Site Mutation (F51L) Develop Severe Obesity Independent of G(s)-alpha/cAMP Signaling
The central melanocortin α-MSH acts through MC4R receptors, which are known to activate G(s)α/cAMP signaling, to promote negative energy balance by inhibiting food intake (FI) and stimulating energy expenditure (EE). However, we have shown that mice with central G(s)α deficiency become obese with de...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Endocrine Society
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554890/ http://dx.doi.org/10.1210/js.2019-OR12-3 |