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OR12-3 Mice with MC4R Site Mutation (F51L) Develop Severe Obesity Independent of G(s)-alpha/cAMP Signaling

The central melanocortin α-MSH acts through MC4R receptors, which are known to activate G(s)α/cAMP signaling, to promote negative energy balance by inhibiting food intake (FI) and stimulating energy expenditure (EE). However, we have shown that mice with central G(s)α deficiency become obese with de...

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Detalles Bibliográficos
Autores principales:	Metzger, Peter, Carlson, Bradley, Sun, Hui, Cui, Zhenzhong, Gavrilova, Oksana, Chen, Min, Weinstein, Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2019
Materias:	Adipose Tissue, Appetite, and Obesity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554890/ http://dx.doi.org/10.1210/js.2019-OR12-3

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