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The GLP-1 agonist, liraglutide, ameliorates inflammation through the activation of the PKA/CREB pathway in a rat model of knee osteoarthritis

BACKGROUND: Inflammation is a common pathological phenomenon of osteoarthritis (OA). Accumulated evidence indicates that ameliorating or suppressing inflammation might be a promising and effective therapeutic strategy for the treatment of OA. Notably, glucagon-like peptide-1 (GLP-1)-based drugs are...

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Detalles Bibliográficos
Autores principales: Que, Qihong, Guo, Xinghua, Zhan, Longxin, Chen, Shaodong, Zhang, Zengli, Ni, Xiaoming, Ye, Bin, Wan, Shuanglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554939/
https://www.ncbi.nlm.nih.gov/pubmed/31182934
http://dx.doi.org/10.1186/s12950-019-0218-y