Therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam to improve outcome in patients with sepsis (TARGET): a prospective, multi-centre, randomised controlled trial

BACKGROUND: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection with a hospital mortality in excess of 40%. Along with insufficient and delayed empirical antimicrobial therapy, inappropriate antimicrobial exposure has been identified to negatively affec...

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Detalles Bibliográficos
Autores principales: Hagel, Stefan, Fiedler, Sandra, Hohn, Andreas, Brinkmann, Alexander, Frey, Otto R., Hoyer, Heike, Schlattmann, Peter, Kiehntopf, Michael, Roberts, Jason A., Pletz, Mathias W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554958/
https://www.ncbi.nlm.nih.gov/pubmed/31171029
http://dx.doi.org/10.1186/s13063-019-3437-x

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