Cargando…

OR22-5 Sotagliflozin Decreases Postprandial Glucose and Insulin by Delaying Intestinal Glucose Absorption

Sotagliflozin (Sota) inhibits sodium glucose cotransporter 2 (SGLT2; IC(50)=1.8 nM) and SGLT1 (IC(50)=36 nM). In humans, Sota improves glycemic control in part by increasing urinary glucose excretion via renal SGLT2 inhibition. Sota also lowers postprandial glucose (PPG), likely by inhibiting intest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Powell, David, Zambrowicz, Brian, Morrow, Linda, Beysen, Carine, Hompesch, Marcus, Turner, Scott, Hellerstein, Marc, Banks, Phillip, Strumph, Paul, Lapuerta, Pablo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2019
Materias:	Diabetes Mellitus and Glucose Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555054/ http://dx.doi.org/10.1210/js.2019-OR22-5

Ejemplares similares

Sotagliflozin Decreases Postprandial Glucose and Insulin Concentrations by Delaying Intestinal Glucose Absorption
por: Powell, David R, et al.
Publicado: (2019)

Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes
por: Sands, Arthur T., et al.
Publicado: (2015)

SUN-146 Glucose Clearance (GLCL) Using Continuous Glucose Monitoring (CGM)
por: Melish, John
Publicado: (2019)

MON-639 Melanocortin 4 Receptor Contributes to Glucose Homeostasis by Regulating Kidney Glucose Reabsorption via the Glucose Transporter GLUT2
por: de Souza Cordeiro, Leticia M, et al.
Publicado: (2020)

OR22-2 Exposure to Hypoglycemia in Older Adults with Type 1 Diabetes: Baseline Characteristics Using Continuous Glucose Monitoring Data
por: Carlson, Anders, et al.
Publicado: (2019)

OR26-01 Epinephrine Is Essential for Normal Renal Glucose Reabsorption via the Glucose Transporter GLUT2
por: Elsheikh, Arwa Mahmoud, et al.
Publicado: (2020)

SAT-146 Short-Term Optimization of Glucose Control Using Self-Monitored Blood Glucose and Standard Therapies
por: Zelada, Henry, et al.
Publicado: (2019)

SUN-LB035 Blood Glucose Trends Documented by Continuous Glucose Monitors Can Be Foundational in the Diagnostic Evaluation of MODY 2
por: Addala, Ananta, et al.
Publicado: (2019)

SAT-127 Hypoglycemic Episodes in Type 2 Diabetes Mellitus : Continuous Glucose Monitoring Versus Self Monitoring of Blood Glucose
por: Aung, Tin, et al.
Publicado: (2019)

OR26-07 Mild Physiologic Hyperglycemia Does Not Affect Glucose Mediated but Impairs Insulin-Mediated Suppression of Plasma Glucagon in Healthy Normal Glucose Tolerant Subjects
por: Tripathy, Devjit, et al.
Publicado: (2020)

MON-635 FDXR Regulates Iron Metabolism and Glucose Metabolism in Liver
por: Sakuma, Ikki, et al.
Publicado: (2020)

Renal GLUT2 is Essential in Regulating Systemic Glucose Homeostasis by Glycosuria
por: de Souza Cordeiro, Leticia M, et al.
Publicado: (2021)

Clinical Utility of 30-Min Postload Plasma Glucose in Paediatric Obesity
por: Poon, Sarah Wing-yiu, et al.
Publicado: (2021)

Insulin Resistant Gestational Glucose Intolerance Is Associated With Adverse Perinatal Outcomes
por: Selen, Daryl J, et al.
Publicado: (2021)

SUN-657 The Effect of Simvastatin on Glucose Metabolism in Primary Human Muscle Cells
por: Mäkinen, Selina, et al.
Publicado: (2020)

SAT-639 Is the Freestyle Libre Flash Glucose Monitor Accurate in the Critically Ill?
por: Johnson-Rabbett, Brianna, et al.
Publicado: (2020)

SAT-664 Fluctuating Blood Glucose in an Infant with Newly Diagnosed IPEX Syndrome
por: Gottesman, Bethany, et al.
Publicado: (2020)

Analysis of Novel Histone Methylase MLL Function for Glucose Metabolism in Mouse Pancreas
por: Yoshino, Satoshi, et al.
Publicado: (2021)

Comparison of Serum Copper, Selenium and Zinc Concentrations Among the States of Glucose Tolerance
por: Pattan, Vishwanath, et al.
Publicado: (2021)

SAT-166 Techniques For Direct Imaging Of Beta-cell Activity And Glucose Homeostasis In Zebrafish
por: Ikle, Jennifer, et al.
Publicado: (2019)

SAT-657 The Gut Microbiome Regulates Host Glucose Homeostasis via Peripheral Serotonin
por: Keating, Damien
Publicado: (2020)

SAT-645 An Indication for Continuous Glucose Monitoring in Glucocorticoid-Treated Patients with Diabetes Mellitus
por: Sandhu, Harjyot, et al.
Publicado: (2020)

Effects of Sodium Glucose Cotransporter 2 Inhibitor on Renal Renin-Angiotensin-Aldsoterone System
por: Takeda, Yoshiyu, et al.
Publicado: (2021)

SAT-648 Flash Glucose Monitoring Helps Achieve Better Glycemic Control Than Conventional Self-Monitoring of Blood Glucose in Non-Insulin-Treated Type 2 Diabetes: A Randomized Controlled Trial
por: Wada, Eri, et al.
Publicado: (2020)

SUN-670 P300 and CBP Are Necessary for Skeletal Muscle Insulin-Stimulated Glucose Uptake
por: Martins, Vitor Fernandes, et al.
Publicado: (2020)

SAT-640 Glycemic Profile of Intravenous Glucocorticoid Induced Hyperglycemia Using Continuous Glucose Monitoring
por: Zhang, Fan, et al.
Publicado: (2020)

Should Target Glucose Values Be Increased to Avoid Severe Hypoglycemia? Real-World Data Say “No.”
por: Welsh, John, et al.
Publicado: (2021)

The Effect of Proton Pump Inhibitors on Insulin-Glucose Homeostasis in Patients With Type 2 Diabetes Mellitus
por: Verma, Vipin, et al.
Publicado: (2021)

OR31-5 Characterization of the One-Hour Plasma Glucose and Plasma Insulin during an Oral Glucose Tolerance Test (OGTT) in Obese Hispanic Children and Adolescents Diagnosed with Prediabetes (Hba1c ≥ 5.7% & ≤ 6.4%)
por: Mehta, Shilpa, et al.
Publicado: (2019)

MON-184 Hypoglycemia During Mixed Meal Tolerance Testing and Early Glucose Dysregulation in Cystic Fibrosis
por: Kilberg, Marissa, et al.
Publicado: (2019)

SAT-LB033 Cryptolepine Action on Insulin Resistance in High-Glucose Diet-Fed Caenorhabditis Elegans
por: Young, Ryan, et al.
Publicado: (2019)

SAT-131 Success of CME/CE in Promoting Practice Improvements in the Use of New Technologies for Glucose Monitoring
por: Larkin, Amy, et al.
Publicado: (2019)

SAT-644 A Case of the Use of the Eversense Continuous Glucose Monitor with Repeated Same-Pocket Insertion
por: Lee, Warren, et al.
Publicado: (2020)

Growth Hormone Receptor Gene Disruption in Mature-Adult Mice Improves Glucose Metabolism and Lifespan in Females
por: Duran-Ortiz, Silvana, et al.
Publicado: (2021)

Influence of Emergency Declaration Over Coronavirus Disease 2019 on Plasma Glucose Control of Patients With Diabetes Mellitus
por: Watanabe, Takuya, et al.
Publicado: (2021)

MON-630 Elevating the Patient Voice in Type 1 Diabetes Clinical Trials: A Comparison of In-Depth Exit Interviews and Diabetes-Specific Questionnaires
por: Ervin, Claire, et al.
Publicado: (2020)

MON-180 Evaluation of the GLUCOCARD Shine Express Audio Enabled Blood Glucose Monitoring System's Ease of Use
por: Walker, Julie, et al.
Publicado: (2019)

MON-LB030 Muscle Mitochondrial Oxidative Phosphorylation Capacity and Whole Body Glucose Metabolism in Friedreich's Ataxia
por: Nguyen, Sara, et al.
Publicado: (2019)

MON-181 Evaluation of the GLUCOCARD Shine Connex Bluetooth Enabled Blood Glucose Monitoring System's Ease of Use
por: Walker, Julie, et al.
Publicado: (2019)

SUN-188 Contributing Factors Precipitation Diabetic Ketoacidosis in Patients Using Sodium-Glucose Cotransporter-2 Inhibitor
por: Attia, Jonven, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_c51u78h2rjb8h13opc3utsm0bf