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A New Pharmacophore Model for the Design of Sigma-1 Ligands Validated on a Large Experimental Dataset
The recent publication of the σ1R crystal structure is an important cornerstone for the derivation of more accurate activity prediction models. We report here a comparative study involving a set of more than 25,000 structures from our internal database that had been screened for σ1R affinity. Using...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555132/ https://www.ncbi.nlm.nih.gov/pubmed/31214020 http://dx.doi.org/10.3389/fphar.2019.00519 |