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Effects of Veratrilla baillonii Extract on Hepatic Gene Expression Profiles in Response to Aconitum brachypodum-Induced Liver Toxicity in Mice

This manuscript was aimed to explore the hepato-protective effect of water extract of Veratrilla baillonii Franch. (Gentianaceae) (WVBF) on serious hepatic toxicity induced in mice treated with Aconitum brachypodum Diels (Ranunculaceae) at transcriptome level. The physiological and pathological symp...

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Autores principales: Li, Jun, Liu, Gang, Ihsan, Awais, Yi, Xuejia, Wang, Da-Gui, Cheng, Han, Muhammad, Azhar, Huang, Xian-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555156/
https://www.ncbi.nlm.nih.gov/pubmed/31214025
http://dx.doi.org/10.3389/fphar.2019.00568
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author Li, Jun
Liu, Gang
Ihsan, Awais
Yi, Xuejia
Wang, Da-Gui
Cheng, Han
Muhammad, Azhar
Huang, Xian-Ju
author_facet Li, Jun
Liu, Gang
Ihsan, Awais
Yi, Xuejia
Wang, Da-Gui
Cheng, Han
Muhammad, Azhar
Huang, Xian-Ju
author_sort Li, Jun
collection PubMed
description This manuscript was aimed to explore the hepato-protective effect of water extract of Veratrilla baillonii Franch. (Gentianaceae) (WVBF) on serious hepatic toxicity induced in mice treated with Aconitum brachypodum Diels (Ranunculaceae) at transcriptome level. The physiological and pathological symptoms were evaluated as the markers for hepato toxicity induced by A. brachypodum Diels (CFA) extracted compounds. Moreover, gene chip method was used to compare and investigate the gene expression level of WVBF on CFA induced-liver toxicity to identify the potential target of WVBF and CFA on liver. The results showed that WVBF had a significant detoxification effect on CFA-induced acute hepatic toxicity. There were 130 genes with lower expression and 124 genes expressed at higher rate in CFA treated group as compared with normal control group, while there are 67 genes down-regulated and 74 genes up-regulated in WVBF treated group in comparison with CFA treated group. WVBF could attenuate CFA-induced liver damage in mice through regulating oxidative stress, inflammatory injury and cell apoptosis/necrosis pathways. On the other hand, WVBF and CFA may have potential synergetic effects on the target genes of certain diseases such as inflammation, cancer and diabetes.
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spelling pubmed-65551562019-06-18 Effects of Veratrilla baillonii Extract on Hepatic Gene Expression Profiles in Response to Aconitum brachypodum-Induced Liver Toxicity in Mice Li, Jun Liu, Gang Ihsan, Awais Yi, Xuejia Wang, Da-Gui Cheng, Han Muhammad, Azhar Huang, Xian-Ju Front Pharmacol Pharmacology This manuscript was aimed to explore the hepato-protective effect of water extract of Veratrilla baillonii Franch. (Gentianaceae) (WVBF) on serious hepatic toxicity induced in mice treated with Aconitum brachypodum Diels (Ranunculaceae) at transcriptome level. The physiological and pathological symptoms were evaluated as the markers for hepato toxicity induced by A. brachypodum Diels (CFA) extracted compounds. Moreover, gene chip method was used to compare and investigate the gene expression level of WVBF on CFA induced-liver toxicity to identify the potential target of WVBF and CFA on liver. The results showed that WVBF had a significant detoxification effect on CFA-induced acute hepatic toxicity. There were 130 genes with lower expression and 124 genes expressed at higher rate in CFA treated group as compared with normal control group, while there are 67 genes down-regulated and 74 genes up-regulated in WVBF treated group in comparison with CFA treated group. WVBF could attenuate CFA-induced liver damage in mice through regulating oxidative stress, inflammatory injury and cell apoptosis/necrosis pathways. On the other hand, WVBF and CFA may have potential synergetic effects on the target genes of certain diseases such as inflammation, cancer and diabetes. Frontiers Media S.A. 2019-05-31 /pmc/articles/PMC6555156/ /pubmed/31214025 http://dx.doi.org/10.3389/fphar.2019.00568 Text en Copyright © 2019 Li, Liu, Ihsan, Yi, Wang, Cheng, Muhammad and Huang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Jun
Liu, Gang
Ihsan, Awais
Yi, Xuejia
Wang, Da-Gui
Cheng, Han
Muhammad, Azhar
Huang, Xian-Ju
Effects of Veratrilla baillonii Extract on Hepatic Gene Expression Profiles in Response to Aconitum brachypodum-Induced Liver Toxicity in Mice
title Effects of Veratrilla baillonii Extract on Hepatic Gene Expression Profiles in Response to Aconitum brachypodum-Induced Liver Toxicity in Mice
title_full Effects of Veratrilla baillonii Extract on Hepatic Gene Expression Profiles in Response to Aconitum brachypodum-Induced Liver Toxicity in Mice
title_fullStr Effects of Veratrilla baillonii Extract on Hepatic Gene Expression Profiles in Response to Aconitum brachypodum-Induced Liver Toxicity in Mice
title_full_unstemmed Effects of Veratrilla baillonii Extract on Hepatic Gene Expression Profiles in Response to Aconitum brachypodum-Induced Liver Toxicity in Mice
title_short Effects of Veratrilla baillonii Extract on Hepatic Gene Expression Profiles in Response to Aconitum brachypodum-Induced Liver Toxicity in Mice
title_sort effects of veratrilla baillonii extract on hepatic gene expression profiles in response to aconitum brachypodum-induced liver toxicity in mice
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555156/
https://www.ncbi.nlm.nih.gov/pubmed/31214025
http://dx.doi.org/10.3389/fphar.2019.00568
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