Elevated Levels of Arachidonic Acid-Derived Lipids Including Prostaglandins and Endocannabinoids Are Present Throughout ABHD12 Knockout Brains: Novel Insights Into the Neurodegenerative Phenotype

Derived from arachidonic acid (AA), the endogenous cannabinoid (eCB) 2-arachidonoyl glycerol (2-AG) is a substrate for α/β hydrolase domain-12 (ABHD12). Loss-of-function mutations of ABHD12 are associated with the neurodegenerative disorder polyneuropathy, hearing loss, ataxia, retinitis pigmentosa,...

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Detalles Bibliográficos
Autores principales: Leishman, Emma, Mackie, Ken, Bradshaw, Heather B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555221/
https://www.ncbi.nlm.nih.gov/pubmed/31213981
http://dx.doi.org/10.3389/fnmol.2019.00142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555221/
https://www.ncbi.nlm.nih.gov/pubmed/31213981
http://dx.doi.org/10.3389/fnmol.2019.00142

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