Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies

FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of...

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Detalles Bibliográficos
Autores principales: Kong, Xiangyi, Zhai, Jie, Yan, Chengrui, Song, Yan, Wang, Jing, Bai, Xiaofeng, Brown, James A. L., Fang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555274/
https://www.ncbi.nlm.nih.gov/pubmed/31214487
http://dx.doi.org/10.3389/fonc.2019.00234
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author Kong, Xiangyi
Zhai, Jie
Yan, Chengrui
Song, Yan
Wang, Jing
Bai, Xiaofeng
Brown, James A. L.
Fang, Yi
author_facet Kong, Xiangyi
Zhai, Jie
Yan, Chengrui
Song, Yan
Wang, Jing
Bai, Xiaofeng
Brown, James A. L.
Fang, Yi
author_sort Kong, Xiangyi
collection PubMed
description FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.
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spelling pubmed-65552742019-06-18 Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies Kong, Xiangyi Zhai, Jie Yan, Chengrui Song, Yan Wang, Jing Bai, Xiaofeng Brown, James A. L. Fang, Yi Front Oncol Oncology FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer. Frontiers Media S.A. 2019-05-31 /pmc/articles/PMC6555274/ /pubmed/31214487 http://dx.doi.org/10.3389/fonc.2019.00234 Text en Copyright © 2019 Kong, Zhai, Yan, Song, Wang, Bai, Brown and Fang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Kong, Xiangyi
Zhai, Jie
Yan, Chengrui
Song, Yan
Wang, Jing
Bai, Xiaofeng
Brown, James A. L.
Fang, Yi
Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies
title Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies
title_full Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies
title_fullStr Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies
title_full_unstemmed Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies
title_short Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies
title_sort recent advances in understanding foxn3 in breast cancer, and other malignancies
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555274/
https://www.ncbi.nlm.nih.gov/pubmed/31214487
http://dx.doi.org/10.3389/fonc.2019.00234
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