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Consequences of Performing Parallel Dose Finding Trials in Heterogeneous Groups of Patients
Patient heterogeneity, in which patients can be grouped by risk of toxicity, is a design challenge in early phase dose finding trials. Carrying out independent trials for each group is a readily available approach for dose finding. However, this often leads to dose recommendations that violate the k...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555302/ https://www.ncbi.nlm.nih.gov/pubmed/31206097 http://dx.doi.org/10.1093/jncics/pkz013 |