Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome

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Loss of function in the Scn1a gene leads to a severe epileptic encephalopathy called Dravet syndrome (DS). Reduced excitability in cortical inhibitory neurons is thought to be the major cause of DS seizures. Here, in contrast, we show enhanced excitability in thalamic inhibitory neurons that promote...

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Detalles Bibliográficos
Autores principales: Ritter-Makinson, Stefanie, Clemente-Perez, Alexandra, Higashikubo, Bryan, Cho, Frances S., Holden, Stephanie S., Bennett, Eric, Chkaidze, Ana, Rooda, Oscar H.J. Eelkman, Cornet, Marie-Coralie, Hoebeek, Freek E., Yamakawa, Kazuhiro, Cilio, Maria Roberta, Delord, Bruno, Paz, Jeanne T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555418/
https://www.ncbi.nlm.nih.gov/pubmed/30605686
http://dx.doi.org/10.1016/j.celrep.2018.12.018

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