Epigenetic clock analysis of human fibroblasts in vitro: effects of hypoxia, donor age, and expression of hTERT and SV40 largeT

Aging is associated with a genome-wide change of DNA methylation (DNAm). "DNAm age" is defined as the predicted chronological age by the age estimator based on DNAm. The estimator is called the epigenetic clock. The molecular mechanism underlining the epigenetic clock is still unknown. Her...

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Detalles Bibliográficos
Autores principales: Matsuyama, Mieko, WuWong, David J., Horvath, Steve, Matsuyama, Shigemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555444/
https://www.ncbi.nlm.nih.gov/pubmed/31113906
http://dx.doi.org/10.18632/aging.101955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555444/
https://www.ncbi.nlm.nih.gov/pubmed/31113906
http://dx.doi.org/10.18632/aging.101955

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