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Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice

Both diabetes and Alzheimer’s disease are age-related disorders, and numerous studies have demonstrated that patients with diabetes are at an increased risk of cognitive dysfunction (CD) and Alzheimer’s disease, suggesting shared or interacting pathomechanisms. The present study investigated the rol...

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Autores principales: Yu, Fan, Han, Wei, Zhan, Gaofeng, Li, Shan, Xiang, Shoukui, Zhu, Bin, Jiang, Xiaohong, Yang, Ling, Luo, Ailin, Hua, Fei, Yang, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555457/
https://www.ncbi.nlm.nih.gov/pubmed/31123221
http://dx.doi.org/10.18632/aging.101978
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author Yu, Fan
Han, Wei
Zhan, Gaofeng
Li, Shan
Xiang, Shoukui
Zhu, Bin
Jiang, Xiaohong
Yang, Ling
Luo, Ailin
Hua, Fei
Yang, Chun
author_facet Yu, Fan
Han, Wei
Zhan, Gaofeng
Li, Shan
Xiang, Shoukui
Zhu, Bin
Jiang, Xiaohong
Yang, Ling
Luo, Ailin
Hua, Fei
Yang, Chun
author_sort Yu, Fan
collection PubMed
description Both diabetes and Alzheimer’s disease are age-related disorders, and numerous studies have demonstrated that patients with diabetes are at an increased risk of cognitive dysfunction (CD) and Alzheimer’s disease, suggesting shared or interacting pathomechanisms. The present study investigated the role of abnormal gut microbiota in diabetes-induced CD and the potential underlying mechanisms. An intraperitoneal injection of streptozotocin administered for 5 consecutive days was used for establishing a diabetic animal model. Hierarchical cluster analysis of Morris water maze (MWM) performance indices (escape latency and target quadrant crossing) was adopted to classify the diabetic model mice into CD and Non-CD phenotypes. Both β-diversity and relative abundance of several gut bacteria significantly differed between the CD and Non-CD groups. Further, fecal bacteria transplantation from Non-CD mice, but not from CD mice, into the gut of pseudo-germ-free mice significantly improved host MWM performance, an effect associated with alterations in β-diversity and relative abundance of host gut bacteria. Collectively, these findings suggest that abnormal gut microbiota composition contributes to the onset of diabetes-induced CD and that improving gut microbiota composition is a potential therapeutic strategy for diabetes and related comorbidities.
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spelling pubmed-65554572019-06-17 Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice Yu, Fan Han, Wei Zhan, Gaofeng Li, Shan Xiang, Shoukui Zhu, Bin Jiang, Xiaohong Yang, Ling Luo, Ailin Hua, Fei Yang, Chun Aging (Albany NY) Research Paper Both diabetes and Alzheimer’s disease are age-related disorders, and numerous studies have demonstrated that patients with diabetes are at an increased risk of cognitive dysfunction (CD) and Alzheimer’s disease, suggesting shared or interacting pathomechanisms. The present study investigated the role of abnormal gut microbiota in diabetes-induced CD and the potential underlying mechanisms. An intraperitoneal injection of streptozotocin administered for 5 consecutive days was used for establishing a diabetic animal model. Hierarchical cluster analysis of Morris water maze (MWM) performance indices (escape latency and target quadrant crossing) was adopted to classify the diabetic model mice into CD and Non-CD phenotypes. Both β-diversity and relative abundance of several gut bacteria significantly differed between the CD and Non-CD groups. Further, fecal bacteria transplantation from Non-CD mice, but not from CD mice, into the gut of pseudo-germ-free mice significantly improved host MWM performance, an effect associated with alterations in β-diversity and relative abundance of host gut bacteria. Collectively, these findings suggest that abnormal gut microbiota composition contributes to the onset of diabetes-induced CD and that improving gut microbiota composition is a potential therapeutic strategy for diabetes and related comorbidities. Impact Journals 2019-05-23 /pmc/articles/PMC6555457/ /pubmed/31123221 http://dx.doi.org/10.18632/aging.101978 Text en Copyright © 2019 Yu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Yu, Fan
Han, Wei
Zhan, Gaofeng
Li, Shan
Xiang, Shoukui
Zhu, Bin
Jiang, Xiaohong
Yang, Ling
Luo, Ailin
Hua, Fei
Yang, Chun
Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice
title Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice
title_full Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice
title_fullStr Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice
title_full_unstemmed Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice
title_short Abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice
title_sort abnormal gut microbiota composition contributes to cognitive dysfunction in streptozotocin-induced diabetic mice
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555457/
https://www.ncbi.nlm.nih.gov/pubmed/31123221
http://dx.doi.org/10.18632/aging.101978
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