Importance of genetic screens in precision oncology

Precision oncology aims to distinguish which patients are eligible for a specific treatment in order to achieve the best possible outcome. In the last few years, genetic screens have shown their potential to find the new targets and drug combinations as well as predictive biomarkers for response and...

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Detalles Bibliográficos
Autores principales: Mulero-Sánchez, Antonio, Pogacar, Ziva, Vecchione, Loredana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555615/
https://www.ncbi.nlm.nih.gov/pubmed/31231569
http://dx.doi.org/10.1136/esmoopen-2019-000505
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author Mulero-Sánchez, Antonio
Pogacar, Ziva
Vecchione, Loredana
author_facet Mulero-Sánchez, Antonio
Pogacar, Ziva
Vecchione, Loredana
author_sort Mulero-Sánchez, Antonio
collection PubMed
description Precision oncology aims to distinguish which patients are eligible for a specific treatment in order to achieve the best possible outcome. In the last few years, genetic screens have shown their potential to find the new targets and drug combinations as well as predictive biomarkers for response and/or resistance to cancer treatment. In this review, we outline how precision oncology is changing over time and describe the different applications of genetic screens. Finally, we present some practical examples that describe the utility and the limitations of genetic screens in precision oncology.
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spelling pubmed-65556152019-06-21 Importance of genetic screens in precision oncology Mulero-Sánchez, Antonio Pogacar, Ziva Vecchione, Loredana ESMO Open Review Precision oncology aims to distinguish which patients are eligible for a specific treatment in order to achieve the best possible outcome. In the last few years, genetic screens have shown their potential to find the new targets and drug combinations as well as predictive biomarkers for response and/or resistance to cancer treatment. In this review, we outline how precision oncology is changing over time and describe the different applications of genetic screens. Finally, we present some practical examples that describe the utility and the limitations of genetic screens in precision oncology. BMJ Publishing Group 2019-05-24 /pmc/articles/PMC6555615/ /pubmed/31231569 http://dx.doi.org/10.1136/esmoopen-2019-000505 Text en © Author (s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ on behalf of the European Society for Medical Oncology. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, any changes made are indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Mulero-Sánchez, Antonio
Pogacar, Ziva
Vecchione, Loredana
Importance of genetic screens in precision oncology
title Importance of genetic screens in precision oncology
title_full Importance of genetic screens in precision oncology
title_fullStr Importance of genetic screens in precision oncology
title_full_unstemmed Importance of genetic screens in precision oncology
title_short Importance of genetic screens in precision oncology
title_sort importance of genetic screens in precision oncology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555615/
https://www.ncbi.nlm.nih.gov/pubmed/31231569
http://dx.doi.org/10.1136/esmoopen-2019-000505
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