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Tyrosine kinase inhibitors relax pulmonary arteries in human and murine precision-cut lung slices

BACKGROUND: Tyrosine kinase inhibitors (TKIs) inhibit the platelet derived growth factor receptor (PDGFR) and gain increasing significance in the therapy of proliferative diseases, e.g. pulmonary arterial hypertension (PAH). Moreover, TKIs relax pulmonary vessels of rats and guinea pigs. So far, it...

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Detalles Bibliográficos
Autores principales:	Rieg, Annette D., Bünting, Nina A., Cranen, Christian, Suleiman, Said, Spillner, Jan W., Schnöring, Heike, Schröder, Thomas, von Stillfried, Saskia, Braunschweig, Till, Manley, Paul W., Schälte, Gereon, Rossaint, Rolf, Uhlig, Stefan, Martin, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555704/ https://www.ncbi.nlm.nih.gov/pubmed/31170998 http://dx.doi.org/10.1186/s12931-019-1074-2

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