Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2)

BACKGROUND: Evidence is conflicting about a causal role of inflammation in psychosis and, specifically, regarding antibodies binding to neuronal membrane targets, especially N-methyl-D-aspartate receptors. NMDAR, LGI1 and GABA-A antibodies were found more prevalent in people with psychosis than in h...

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Detalles Bibliográficos
Autores principales: Lennox, Belinda, Yeeles, Ksenija, Jones, Peter B., Zandi, Michael, Joyce, Eileen, Yu, Ly-Mee, Tomei, Giuliano, Pollard, Rebecca, Vincent, Sally-Anne, Shimazaki, Mio, Cairns, Iona, Dowling, Francis, Kabir, Thomas, Barnes, Thomas R. E., Lingford Hughes, Anne, Hosseini, Akram A., Harrower, Timothy, Buckley, Camilla, Coles, Alasdair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555751/
https://www.ncbi.nlm.nih.gov/pubmed/31174586
http://dx.doi.org/10.1186/s13063-019-3336-1

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