Cargando…
Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study
BACKGROUND: Chronic kidney disease is a known risk factor for end-stage renal and cardiovascular diseases. However, data are limited on the causes of hospitalization in patients with chronic kidney disease of maintenance period. This study aimed to aggregate hospitalization data of CKD patients and...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Singapore
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555784/ https://www.ncbi.nlm.nih.gov/pubmed/30968244 http://dx.doi.org/10.1007/s10157-019-01730-9 |
_version_ | 1783425209530843136 |
---|---|
author | Iimuro, Satoshi Kaneko, Tetsuji Ohashi, Yasuo Watanabe, Tsuyoshi Nitta, Kosaku Akizawa, Tadao Matsuo, Seiichi Imai, Enyu Makino, Hirofumi Hishida, Akira |
author_facet | Iimuro, Satoshi Kaneko, Tetsuji Ohashi, Yasuo Watanabe, Tsuyoshi Nitta, Kosaku Akizawa, Tadao Matsuo, Seiichi Imai, Enyu Makino, Hirofumi Hishida, Akira |
author_sort | Iimuro, Satoshi |
collection | PubMed |
description | BACKGROUND: Chronic kidney disease is a known risk factor for end-stage renal and cardiovascular diseases. However, data are limited on the causes of hospitalization in patients with chronic kidney disease of maintenance period. This study aimed to aggregate hospitalization data of CKD patients and to determine the high-risk population. In addition, we compared CKD population to general population. METHODS: We conducted a post hoc analysis of the chronic kidney disease-Japan cohort study, a multicenter prospective cohort study of 2966 patients with chronic kidney disease with a median 3.9 years of follow-up. We examined the hospitalization reasons and analyzed the risk factors. RESULTS: We found 2897 all-cause hospitalization events (252.3 events/1000 person-years), a hospitalization incidence 17.1-fold higher than that in an age- and sex-matched cohort from the general Japanese population. Kidney, eye and adnexa, and heart-related hospital admissions were the most common. All-cause hospitalization increased with chronic kidney disease stage and with the presence of diabetes. Patients with diabetes at enrollment had 345.7 hospitalization events/1000 person-years, which is considerably higher than 196.8 events/1000 person-years for those without diabetes. Survival analysis, using hospitalization as an event, showed earlier all-cause hospitalization with the progression of chronic kidney disease stage and diabetes. Cardiovascular disease hospitalizations were more strongly influenced by diabetes than chronic kidney disease stage. CONCLUSIONS: Patients with chronic kidney disease and diabetes are highly vulnerable to hospitalization for a variety of diseases. These descriptive data can be valuable in predicting the prognosis of patients with chronic kidney disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10157-019-01730-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6555784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-65557842019-06-21 Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study Iimuro, Satoshi Kaneko, Tetsuji Ohashi, Yasuo Watanabe, Tsuyoshi Nitta, Kosaku Akizawa, Tadao Matsuo, Seiichi Imai, Enyu Makino, Hirofumi Hishida, Akira Clin Exp Nephrol Original Article BACKGROUND: Chronic kidney disease is a known risk factor for end-stage renal and cardiovascular diseases. However, data are limited on the causes of hospitalization in patients with chronic kidney disease of maintenance period. This study aimed to aggregate hospitalization data of CKD patients and to determine the high-risk population. In addition, we compared CKD population to general population. METHODS: We conducted a post hoc analysis of the chronic kidney disease-Japan cohort study, a multicenter prospective cohort study of 2966 patients with chronic kidney disease with a median 3.9 years of follow-up. We examined the hospitalization reasons and analyzed the risk factors. RESULTS: We found 2897 all-cause hospitalization events (252.3 events/1000 person-years), a hospitalization incidence 17.1-fold higher than that in an age- and sex-matched cohort from the general Japanese population. Kidney, eye and adnexa, and heart-related hospital admissions were the most common. All-cause hospitalization increased with chronic kidney disease stage and with the presence of diabetes. Patients with diabetes at enrollment had 345.7 hospitalization events/1000 person-years, which is considerably higher than 196.8 events/1000 person-years for those without diabetes. Survival analysis, using hospitalization as an event, showed earlier all-cause hospitalization with the progression of chronic kidney disease stage and diabetes. Cardiovascular disease hospitalizations were more strongly influenced by diabetes than chronic kidney disease stage. CONCLUSIONS: Patients with chronic kidney disease and diabetes are highly vulnerable to hospitalization for a variety of diseases. These descriptive data can be valuable in predicting the prognosis of patients with chronic kidney disease. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10157-019-01730-9) contains supplementary material, which is available to authorized users. Springer Singapore 2019-04-09 2019 /pmc/articles/PMC6555784/ /pubmed/30968244 http://dx.doi.org/10.1007/s10157-019-01730-9 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Iimuro, Satoshi Kaneko, Tetsuji Ohashi, Yasuo Watanabe, Tsuyoshi Nitta, Kosaku Akizawa, Tadao Matsuo, Seiichi Imai, Enyu Makino, Hirofumi Hishida, Akira Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study |
title | Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study |
title_full | Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study |
title_fullStr | Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study |
title_full_unstemmed | Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study |
title_short | Analysis of 2897 hospitalization events for patients with chronic kidney disease: results from CKD-JAC study |
title_sort | analysis of 2897 hospitalization events for patients with chronic kidney disease: results from ckd-jac study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555784/ https://www.ncbi.nlm.nih.gov/pubmed/30968244 http://dx.doi.org/10.1007/s10157-019-01730-9 |
work_keys_str_mv | AT iimurosatoshi analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy AT kanekotetsuji analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy AT ohashiyasuo analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy AT watanabetsuyoshi analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy AT nittakosaku analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy AT akizawatadao analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy AT matsuoseiichi analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy AT imaienyu analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy AT makinohirofumi analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy AT hishidaakira analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy AT analysisof2897hospitalizationeventsforpatientswithchronickidneydiseaseresultsfromckdjacstudy |