CHML promotes liver cancer metastasis by facilitating Rab14 recycle

Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurren...

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Detalles Bibliográficos
Autores principales: Chen, Tian-Wei, Yin, Fen-Fen, Yuan, Yan-Mei, Guan, Dong-Xian, Zhang, Erbin, Zhang, Feng-Kun, Jiang, Hao, Ma, Ning, Wang, Jing-Jing, Ni, Qian-Zhi, Qiu, Lin, Feng, Jing, Zhang, Xue-Li, Bao, Ying, Wang, Kang, Cheng, Shu-Qun, Wang, Xiao-Fan, Wang, Xiang, Li, Jing-Jing, Xie, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555802/
https://www.ncbi.nlm.nih.gov/pubmed/31175290
http://dx.doi.org/10.1038/s41467-019-10364-0
Descripción
Sumario:Metastasis-associated recurrence is the major cause of poor prognosis in hepatocellular carcinoma (HCC), however, the underlying mechanisms remain largely elusive. In this study, we report that expression of choroideremia-like (CHML) is increased in HCC, associated with poor survival, early recurrence and more satellite nodules in HCC patients. CHML promotes migration, invasion and metastasis of HCC cells, in a Rab14-dependent manner. Mechanism study reveals that CHML facilitates constant recycling of Rab14 by escorting Rab14 to the membrane. Furthermore, we identify several metastasis regulators as cargoes carried by Rab14-positive vesicles, including Mucin13 and CD44, which may contribute to metastasis-promoting effects of CHML. Altogether, our data establish CHML as a potential promoter of HCC metastasis, and the CHML-Rab14 axis may be a promising therapeutic target for HCC.

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