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Codon usage optimization in pluripotent embryonic stem cells

BACKGROUND: The uneven use of synonymous codons in the transcriptome regulates the efficiency and fidelity of protein translation rates. Yet, the importance of this codon bias in regulating cell state-specific expression programmes is currently debated. Here, we ask whether different codon usage con...

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Detalles Bibliográficos
Autores principales:	Bornelöv, Susanne, Selmi, Tommaso, Flad, Sophia, Dietmann, Sabine, Frye, Michaela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555954/ https://www.ncbi.nlm.nih.gov/pubmed/31174582 http://dx.doi.org/10.1186/s13059-019-1726-z

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