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CYFIP1 overexpression increases fear response in mice but does not affect social or repetitive behavioral phenotypes

BACKGROUND: CYFIP1, a protein that interacts with FMRP and regulates protein synthesis and actin dynamics, is overexpressed in Dup15q syndrome as well as autism spectrum disorder (ASD). While CYFIP1 heterozygosity has been rigorously studied due to its loss in 15q11.2 deletion, Prader-Willi and Ange...

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Detalles Bibliográficos
Autores principales:	Fricano-Kugler, Catherine, Gordon, Aaron, Shin, Grace, Gao, Kun, Nguyen, Jade, Berg, Jamee, Starks, Mary, Geschwind, Daniel H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555997/ https://www.ncbi.nlm.nih.gov/pubmed/31198525 http://dx.doi.org/10.1186/s13229-019-0278-0

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