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Splenic Blood Flow Increases after Hypothermic Stimulus (Cold Pressor Test): A Perfusion Magnetic Resonance Study

The Cold Pressor Test (CPT) is a novel diagnostic strategy to noninvasively assess the myocardial microvascular endothelial-dependent function using perfusion magnetic resonance imaging (MRI). Spleen perfusion is modulated by a complex combination of several mechanisms involving the autonomic nervou...

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Autores principales: Galea, Nicola, Cundari, Giulia, Borrazzo, Cristian, Pambianchi, Giacomo, Bracci, Angelica, Rosato, Edoardo, Francone, Marco, Carbone, Iacopo, Catalano, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556242/
https://www.ncbi.nlm.nih.gov/pubmed/31240227
http://dx.doi.org/10.1155/2019/8437927
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author Galea, Nicola
Cundari, Giulia
Borrazzo, Cristian
Pambianchi, Giacomo
Bracci, Angelica
Rosato, Edoardo
Francone, Marco
Carbone, Iacopo
Catalano, Carlo
author_facet Galea, Nicola
Cundari, Giulia
Borrazzo, Cristian
Pambianchi, Giacomo
Bracci, Angelica
Rosato, Edoardo
Francone, Marco
Carbone, Iacopo
Catalano, Carlo
author_sort Galea, Nicola
collection PubMed
description The Cold Pressor Test (CPT) is a novel diagnostic strategy to noninvasively assess the myocardial microvascular endothelial-dependent function using perfusion magnetic resonance imaging (MRI). Spleen perfusion is modulated by a complex combination of several mechanisms involving the autonomic nervous system and vasoactive mediators release. In this context, the effects of cold temperature on splenic blood flow (SBF) still need to be clarified. Ten healthy subjects were studied by MRI. MRI protocol included the acquisition of GRE T1-weighted sequence (“first pass perfusion”) during gadolinium administration (0.1mmol/kg of Gd-DOTA at flow of 3.0 ml/s), at rest and after CPT. Myocardial blood flow (MBF) and SBF were measured by applying Fermi function deconvolution, using the blood pool input function sampled from the left ventricle cavity. MBF and SBF values after performing CPT were significantly higher than rest values (SBF at rest: 0.65 ± 0.15 ml/min/g Vs. SBF after CPT: 0.90 ± 0.14 ml/min/g, p: <0.001; MBF at rest: 0.90 ± 0.068 ml/min/g Vs. MBF after CPT: 1.22 ± 0.098 ml/min/g, p<0.005). Both SBF and MBF increased in all patients during the CPT. In particular, the CPT-induced increase was 43% ± 29% for SBF and 36.5% ± 17% for MBF. CPT increases SBF in normal subjects. The characterization of a standard perfusion response to cold might allow the use of the spleen as reference marker for the adequacy of cold stimulation during myocardial perfusion MRI.
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spelling pubmed-65562422019-06-25 Splenic Blood Flow Increases after Hypothermic Stimulus (Cold Pressor Test): A Perfusion Magnetic Resonance Study Galea, Nicola Cundari, Giulia Borrazzo, Cristian Pambianchi, Giacomo Bracci, Angelica Rosato, Edoardo Francone, Marco Carbone, Iacopo Catalano, Carlo Biomed Res Int Research Article The Cold Pressor Test (CPT) is a novel diagnostic strategy to noninvasively assess the myocardial microvascular endothelial-dependent function using perfusion magnetic resonance imaging (MRI). Spleen perfusion is modulated by a complex combination of several mechanisms involving the autonomic nervous system and vasoactive mediators release. In this context, the effects of cold temperature on splenic blood flow (SBF) still need to be clarified. Ten healthy subjects were studied by MRI. MRI protocol included the acquisition of GRE T1-weighted sequence (“first pass perfusion”) during gadolinium administration (0.1mmol/kg of Gd-DOTA at flow of 3.0 ml/s), at rest and after CPT. Myocardial blood flow (MBF) and SBF were measured by applying Fermi function deconvolution, using the blood pool input function sampled from the left ventricle cavity. MBF and SBF values after performing CPT were significantly higher than rest values (SBF at rest: 0.65 ± 0.15 ml/min/g Vs. SBF after CPT: 0.90 ± 0.14 ml/min/g, p: <0.001; MBF at rest: 0.90 ± 0.068 ml/min/g Vs. MBF after CPT: 1.22 ± 0.098 ml/min/g, p<0.005). Both SBF and MBF increased in all patients during the CPT. In particular, the CPT-induced increase was 43% ± 29% for SBF and 36.5% ± 17% for MBF. CPT increases SBF in normal subjects. The characterization of a standard perfusion response to cold might allow the use of the spleen as reference marker for the adequacy of cold stimulation during myocardial perfusion MRI. Hindawi 2019-05-23 /pmc/articles/PMC6556242/ /pubmed/31240227 http://dx.doi.org/10.1155/2019/8437927 Text en Copyright © 2019 Nicola Galea et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Galea, Nicola
Cundari, Giulia
Borrazzo, Cristian
Pambianchi, Giacomo
Bracci, Angelica
Rosato, Edoardo
Francone, Marco
Carbone, Iacopo
Catalano, Carlo
Splenic Blood Flow Increases after Hypothermic Stimulus (Cold Pressor Test): A Perfusion Magnetic Resonance Study
title Splenic Blood Flow Increases after Hypothermic Stimulus (Cold Pressor Test): A Perfusion Magnetic Resonance Study
title_full Splenic Blood Flow Increases after Hypothermic Stimulus (Cold Pressor Test): A Perfusion Magnetic Resonance Study
title_fullStr Splenic Blood Flow Increases after Hypothermic Stimulus (Cold Pressor Test): A Perfusion Magnetic Resonance Study
title_full_unstemmed Splenic Blood Flow Increases after Hypothermic Stimulus (Cold Pressor Test): A Perfusion Magnetic Resonance Study
title_short Splenic Blood Flow Increases after Hypothermic Stimulus (Cold Pressor Test): A Perfusion Magnetic Resonance Study
title_sort splenic blood flow increases after hypothermic stimulus (cold pressor test): a perfusion magnetic resonance study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556242/
https://www.ncbi.nlm.nih.gov/pubmed/31240227
http://dx.doi.org/10.1155/2019/8437927
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