A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy

In the past decade, nanomedicine research has provided us with highly useful agents (nanoparticles) delivering therapeutic drugs to target cancer cells. The present review highlights nanomedicine applications for breast cancer immunotherapy. Recent studies have suggested that tumour necrosis factor...

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Autores principales: Al-Hatamleh, Mohammad A. I., Ahmad, Suhana, Boer, Jennifer C., Lim, JitKang, Chen, Xin, Plebanski, Magdalena, Mohamud, Rohimah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556275/
https://www.ncbi.nlm.nih.gov/pubmed/31239840
http://dx.doi.org/10.1155/2019/6313242
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author Al-Hatamleh, Mohammad A. I.
Ahmad, Suhana
Boer, Jennifer C.
Lim, JitKang
Chen, Xin
Plebanski, Magdalena
Mohamud, Rohimah
author_facet Al-Hatamleh, Mohammad A. I.
Ahmad, Suhana
Boer, Jennifer C.
Lim, JitKang
Chen, Xin
Plebanski, Magdalena
Mohamud, Rohimah
author_sort Al-Hatamleh, Mohammad A. I.
collection PubMed
description In the past decade, nanomedicine research has provided us with highly useful agents (nanoparticles) delivering therapeutic drugs to target cancer cells. The present review highlights nanomedicine applications for breast cancer immunotherapy. Recent studies have suggested that tumour necrosis factor (TNF) and its receptor 2 (TNFR2) expressed on breast cancer cells have important functional consequences. This cytokine/receptor interaction is also critical for promoting highly immune-suppressive phenotypes by regulatory T cells (Tregs). This review generally provides a background for nanoparticles as potential drug delivery agents for immunomodulators and further discusses in depth the potential of TNF antagonists delivery to modulate TNF-TNFR2 interactions and inhibit breast cancer progression.
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spelling pubmed-65562752019-06-25 A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy Al-Hatamleh, Mohammad A. I. Ahmad, Suhana Boer, Jennifer C. Lim, JitKang Chen, Xin Plebanski, Magdalena Mohamud, Rohimah J Oncol Review Article In the past decade, nanomedicine research has provided us with highly useful agents (nanoparticles) delivering therapeutic drugs to target cancer cells. The present review highlights nanomedicine applications for breast cancer immunotherapy. Recent studies have suggested that tumour necrosis factor (TNF) and its receptor 2 (TNFR2) expressed on breast cancer cells have important functional consequences. This cytokine/receptor interaction is also critical for promoting highly immune-suppressive phenotypes by regulatory T cells (Tregs). This review generally provides a background for nanoparticles as potential drug delivery agents for immunomodulators and further discusses in depth the potential of TNF antagonists delivery to modulate TNF-TNFR2 interactions and inhibit breast cancer progression. Hindawi 2019-05-23 /pmc/articles/PMC6556275/ /pubmed/31239840 http://dx.doi.org/10.1155/2019/6313242 Text en Copyright © 2019 Mohammad A. I. Al-Hatamleh et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Al-Hatamleh, Mohammad A. I.
Ahmad, Suhana
Boer, Jennifer C.
Lim, JitKang
Chen, Xin
Plebanski, Magdalena
Mohamud, Rohimah
A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy
title A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy
title_full A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy
title_fullStr A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy
title_full_unstemmed A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy
title_short A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy
title_sort perspective review on the role of nanomedicine in the modulation of tnf-tnfr2 axis in breast cancer immunotherapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556275/
https://www.ncbi.nlm.nih.gov/pubmed/31239840
http://dx.doi.org/10.1155/2019/6313242
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