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Quality of Life in Painful Peripheral Neuropathies: A Systematic Review

OBJECTIVE: Neuropathic pain is a common presenting complaint of patients with peripheral neuropathy (PN) and is considered one of the most disabling neuropathic symptoms, with detrimental effects on patients' quality of life (QoL). The aim of this review was to overview the current literature t...

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Autores principales: Girach, Ayesha, Julian, Thomas Henry, Varrassi, Giustino, Paladini, Antonella, Vadalouka, Athina, Zis, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556282/
https://www.ncbi.nlm.nih.gov/pubmed/31249636
http://dx.doi.org/10.1155/2019/2091960
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author Girach, Ayesha
Julian, Thomas Henry
Varrassi, Giustino
Paladini, Antonella
Vadalouka, Athina
Zis, Panagiotis
author_facet Girach, Ayesha
Julian, Thomas Henry
Varrassi, Giustino
Paladini, Antonella
Vadalouka, Athina
Zis, Panagiotis
author_sort Girach, Ayesha
collection PubMed
description OBJECTIVE: Neuropathic pain is a common presenting complaint of patients with peripheral neuropathy (PN) and is considered one of the most disabling neuropathic symptoms, with detrimental effects on patients' quality of life (QoL). The aim of this review was to overview the current literature that focuses on QoL in painful PN of various aetiologies. We sought to clarify the direct effect of pain and its treatment on patients' QoL. METHODOLOGY: A systematic computer-based literature search was conducted using the PubMed database to search for papers on QoL in painful PN. Information was extracted regarding prevalence, demographics, and response to treatment where relevant. RESULTS: We identified 66 articles eligible for inclusion. The vast majority of studies (n=47) focused on patients with diabetic PN. Other aetiologies of painful PN where QoL has been studied to date include gluten, immune-mediated, HIV, chemotherapy-induced, and chronic idiopathic axonal polyneuropathy. Pharmacological treatment is the mainstay in managing pain and has a direct positive and independent effect on the overall QoL. Other nonpharmacological approaches can also be of benefit, either alone or as adjuvant treatments, and are discussed. CONCLUSION: The findings demonstrate that QoL is impaired in painful PN and should not be neglected in clinical practice. Patients' pain management and subsequent impact on QoL should routinely be assessed and monitored.
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spelling pubmed-65562822019-06-27 Quality of Life in Painful Peripheral Neuropathies: A Systematic Review Girach, Ayesha Julian, Thomas Henry Varrassi, Giustino Paladini, Antonella Vadalouka, Athina Zis, Panagiotis Pain Res Manag Review Article OBJECTIVE: Neuropathic pain is a common presenting complaint of patients with peripheral neuropathy (PN) and is considered one of the most disabling neuropathic symptoms, with detrimental effects on patients' quality of life (QoL). The aim of this review was to overview the current literature that focuses on QoL in painful PN of various aetiologies. We sought to clarify the direct effect of pain and its treatment on patients' QoL. METHODOLOGY: A systematic computer-based literature search was conducted using the PubMed database to search for papers on QoL in painful PN. Information was extracted regarding prevalence, demographics, and response to treatment where relevant. RESULTS: We identified 66 articles eligible for inclusion. The vast majority of studies (n=47) focused on patients with diabetic PN. Other aetiologies of painful PN where QoL has been studied to date include gluten, immune-mediated, HIV, chemotherapy-induced, and chronic idiopathic axonal polyneuropathy. Pharmacological treatment is the mainstay in managing pain and has a direct positive and independent effect on the overall QoL. Other nonpharmacological approaches can also be of benefit, either alone or as adjuvant treatments, and are discussed. CONCLUSION: The findings demonstrate that QoL is impaired in painful PN and should not be neglected in clinical practice. Patients' pain management and subsequent impact on QoL should routinely be assessed and monitored. Hindawi 2019-05-23 /pmc/articles/PMC6556282/ /pubmed/31249636 http://dx.doi.org/10.1155/2019/2091960 Text en Copyright © 2019 Ayesha Girach et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Girach, Ayesha
Julian, Thomas Henry
Varrassi, Giustino
Paladini, Antonella
Vadalouka, Athina
Zis, Panagiotis
Quality of Life in Painful Peripheral Neuropathies: A Systematic Review
title Quality of Life in Painful Peripheral Neuropathies: A Systematic Review
title_full Quality of Life in Painful Peripheral Neuropathies: A Systematic Review
title_fullStr Quality of Life in Painful Peripheral Neuropathies: A Systematic Review
title_full_unstemmed Quality of Life in Painful Peripheral Neuropathies: A Systematic Review
title_short Quality of Life in Painful Peripheral Neuropathies: A Systematic Review
title_sort quality of life in painful peripheral neuropathies: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556282/
https://www.ncbi.nlm.nih.gov/pubmed/31249636
http://dx.doi.org/10.1155/2019/2091960
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