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Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic, systemic, autoimmune inflammatory disease characterized by the production of numerous autoantibodies and cytokines, as well as multiple organ damage. Specific B cell subsets negatively regulate immune responses and have been termed regulatory B cells...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556307/ https://www.ncbi.nlm.nih.gov/pubmed/31240224 http://dx.doi.org/10.1155/2019/7948687 |
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author | Wang, Tao Mei, Yongjun Li, Zhijun |
author_facet | Wang, Tao Mei, Yongjun Li, Zhijun |
author_sort | Wang, Tao |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) is a chronic, systemic, autoimmune inflammatory disease characterized by the production of numerous autoantibodies and cytokines, as well as multiple organ damage. Specific B cell subsets negatively regulate immune responses and have been termed regulatory B cells (Bregs). Bregs are characterized by the production of the immunoregulatory cytokines interleukin (IL)-10, IL-35, and transforming growth factor (TGF)-β. Bregs suppress other immune cells through the secretion of these immunosuppressive cytokines and have thus been studied extensively for their potential role in the treatment of various autoimmune diseases. The progress of the research on Bregs and SLE in recent years is reviewed in this paper. |
format | Online Article Text |
id | pubmed-6556307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65563072019-06-25 Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus Wang, Tao Mei, Yongjun Li, Zhijun Biomed Res Int Review Article Systemic lupus erythematosus (SLE) is a chronic, systemic, autoimmune inflammatory disease characterized by the production of numerous autoantibodies and cytokines, as well as multiple organ damage. Specific B cell subsets negatively regulate immune responses and have been termed regulatory B cells (Bregs). Bregs are characterized by the production of the immunoregulatory cytokines interleukin (IL)-10, IL-35, and transforming growth factor (TGF)-β. Bregs suppress other immune cells through the secretion of these immunosuppressive cytokines and have thus been studied extensively for their potential role in the treatment of various autoimmune diseases. The progress of the research on Bregs and SLE in recent years is reviewed in this paper. Hindawi 2019-05-22 /pmc/articles/PMC6556307/ /pubmed/31240224 http://dx.doi.org/10.1155/2019/7948687 Text en Copyright © 2019 Tao Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Wang, Tao Mei, Yongjun Li, Zhijun Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus |
title | Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus |
title_full | Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus |
title_fullStr | Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus |
title_full_unstemmed | Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus |
title_short | Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus |
title_sort | research progress on regulatory b cells in systemic lupus erythematosus |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556307/ https://www.ncbi.nlm.nih.gov/pubmed/31240224 http://dx.doi.org/10.1155/2019/7948687 |
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