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Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a chronic, systemic, autoimmune inflammatory disease characterized by the production of numerous autoantibodies and cytokines, as well as multiple organ damage. Specific B cell subsets negatively regulate immune responses and have been termed regulatory B cells...

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Detalles Bibliográficos
Autores principales: Wang, Tao, Mei, Yongjun, Li, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556307/
https://www.ncbi.nlm.nih.gov/pubmed/31240224
http://dx.doi.org/10.1155/2019/7948687
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author Wang, Tao
Mei, Yongjun
Li, Zhijun
author_facet Wang, Tao
Mei, Yongjun
Li, Zhijun
author_sort Wang, Tao
collection PubMed
description Systemic lupus erythematosus (SLE) is a chronic, systemic, autoimmune inflammatory disease characterized by the production of numerous autoantibodies and cytokines, as well as multiple organ damage. Specific B cell subsets negatively regulate immune responses and have been termed regulatory B cells (Bregs). Bregs are characterized by the production of the immunoregulatory cytokines interleukin (IL)-10, IL-35, and transforming growth factor (TGF)-β. Bregs suppress other immune cells through the secretion of these immunosuppressive cytokines and have thus been studied extensively for their potential role in the treatment of various autoimmune diseases. The progress of the research on Bregs and SLE in recent years is reviewed in this paper.
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spelling pubmed-65563072019-06-25 Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus Wang, Tao Mei, Yongjun Li, Zhijun Biomed Res Int Review Article Systemic lupus erythematosus (SLE) is a chronic, systemic, autoimmune inflammatory disease characterized by the production of numerous autoantibodies and cytokines, as well as multiple organ damage. Specific B cell subsets negatively regulate immune responses and have been termed regulatory B cells (Bregs). Bregs are characterized by the production of the immunoregulatory cytokines interleukin (IL)-10, IL-35, and transforming growth factor (TGF)-β. Bregs suppress other immune cells through the secretion of these immunosuppressive cytokines and have thus been studied extensively for their potential role in the treatment of various autoimmune diseases. The progress of the research on Bregs and SLE in recent years is reviewed in this paper. Hindawi 2019-05-22 /pmc/articles/PMC6556307/ /pubmed/31240224 http://dx.doi.org/10.1155/2019/7948687 Text en Copyright © 2019 Tao Wang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Tao
Mei, Yongjun
Li, Zhijun
Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus
title Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus
title_full Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus
title_fullStr Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus
title_full_unstemmed Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus
title_short Research Progress on Regulatory B Cells in Systemic Lupus Erythematosus
title_sort research progress on regulatory b cells in systemic lupus erythematosus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556307/
https://www.ncbi.nlm.nih.gov/pubmed/31240224
http://dx.doi.org/10.1155/2019/7948687
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