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Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice

Diabetes mellitus (DM) is a metabolic disease that can affect the central nervous system and behavioral traits in animals. Streptozotocin-induced diabetes is considered an autoimmune disease. The aim of the current study was to determine whether supplementation with the alcoholic extract of Avicenni...

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Autores principales: Okla, Mohammad K., Alamri, Saud A., Alatar, Abdulrahman A., Hegazy, Ahmed K., Al-Ghamdi, Abdullah A., Ajarem, Jamaan S., Faisal, Mohammad, Abdel-Salam, Eslam M., Ali, Hayssam M., Salem, Mohamed Z. M., Abdel-Maksoud, Mostafa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556331/
https://www.ncbi.nlm.nih.gov/pubmed/31239852
http://dx.doi.org/10.1155/2019/1263260
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author Okla, Mohammad K.
Alamri, Saud A.
Alatar, Abdulrahman A.
Hegazy, Ahmed K.
Al-Ghamdi, Abdullah A.
Ajarem, Jamaan S.
Faisal, Mohammad
Abdel-Salam, Eslam M.
Ali, Hayssam M.
Salem, Mohamed Z. M.
Abdel-Maksoud, Mostafa A.
author_facet Okla, Mohammad K.
Alamri, Saud A.
Alatar, Abdulrahman A.
Hegazy, Ahmed K.
Al-Ghamdi, Abdullah A.
Ajarem, Jamaan S.
Faisal, Mohammad
Abdel-Salam, Eslam M.
Ali, Hayssam M.
Salem, Mohamed Z. M.
Abdel-Maksoud, Mostafa A.
author_sort Okla, Mohammad K.
collection PubMed
description Diabetes mellitus (DM) is a metabolic disease that can affect the central nervous system and behavioral traits in animals. Streptozotocin-induced diabetes is considered an autoimmune disease. The aim of the current study was to determine whether supplementation with the alcoholic extract of Avicennia marina leaves could improve diabetes-associated pathological changes. The animals were divided into four groups: a control group (A), an A. marina receiving nondiabetic group (B), a diabetic group (C), and a DM group orally supplemented with A. marina alcoholic leaf extract (D). The DM group of animals receiving the alcoholic extract of A. marina leaves had reduced blood glucose levels, improved blood picture, and organ functions. This group also showed improvement in locomotory behavior. The results of this study showed that supplementation with the alcoholic extract of A. marina leaves reduced oxidative stress and blood sugar levels, protected the liver, and improved the neurobehavioral changes associated with diabetes in mice. Introducing alcoholic leaf extract of A. marina to diabetic mice decreased inflammatory cells aggregation, vacuolation, and hemorrhage. Additionally, a positive effect of the alcoholic leaf extract on the histopathological changes was observed in the testicular tissue of treated mice.
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spelling pubmed-65563312019-06-25 Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice Okla, Mohammad K. Alamri, Saud A. Alatar, Abdulrahman A. Hegazy, Ahmed K. Al-Ghamdi, Abdullah A. Ajarem, Jamaan S. Faisal, Mohammad Abdel-Salam, Eslam M. Ali, Hayssam M. Salem, Mohamed Z. M. Abdel-Maksoud, Mostafa A. Evid Based Complement Alternat Med Research Article Diabetes mellitus (DM) is a metabolic disease that can affect the central nervous system and behavioral traits in animals. Streptozotocin-induced diabetes is considered an autoimmune disease. The aim of the current study was to determine whether supplementation with the alcoholic extract of Avicennia marina leaves could improve diabetes-associated pathological changes. The animals were divided into four groups: a control group (A), an A. marina receiving nondiabetic group (B), a diabetic group (C), and a DM group orally supplemented with A. marina alcoholic leaf extract (D). The DM group of animals receiving the alcoholic extract of A. marina leaves had reduced blood glucose levels, improved blood picture, and organ functions. This group also showed improvement in locomotory behavior. The results of this study showed that supplementation with the alcoholic extract of A. marina leaves reduced oxidative stress and blood sugar levels, protected the liver, and improved the neurobehavioral changes associated with diabetes in mice. Introducing alcoholic leaf extract of A. marina to diabetic mice decreased inflammatory cells aggregation, vacuolation, and hemorrhage. Additionally, a positive effect of the alcoholic leaf extract on the histopathological changes was observed in the testicular tissue of treated mice. Hindawi 2019-05-21 /pmc/articles/PMC6556331/ /pubmed/31239852 http://dx.doi.org/10.1155/2019/1263260 Text en Copyright © 2019 Mohammad K. Okla et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Okla, Mohammad K.
Alamri, Saud A.
Alatar, Abdulrahman A.
Hegazy, Ahmed K.
Al-Ghamdi, Abdullah A.
Ajarem, Jamaan S.
Faisal, Mohammad
Abdel-Salam, Eslam M.
Ali, Hayssam M.
Salem, Mohamed Z. M.
Abdel-Maksoud, Mostafa A.
Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice
title Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice
title_full Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice
title_fullStr Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice
title_full_unstemmed Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice
title_short Antioxidant, Hypoglycemic, and Neurobehavioral Effects of a Leaf Extract of Avicennia marina on Autoimmune Diabetic Mice
title_sort antioxidant, hypoglycemic, and neurobehavioral effects of a leaf extract of avicennia marina on autoimmune diabetic mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556331/
https://www.ncbi.nlm.nih.gov/pubmed/31239852
http://dx.doi.org/10.1155/2019/1263260
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