Cargando…

Zoledronic acid exhibits radio-sensitizing activity in human pancreatic cancer cells via inactivation of STAT3/NF-κB signaling

Background: Although pancreatic cancer is typically radio-sensitive, local treatment failure and metastasis are commonly caused by the development of resistance to radiotherapy. In the current study, the radio-sensitizing actions of zoledronic acid (ZOL) on pancreatic cancer cells were investigated....

Descripción completa

Detalles Bibliográficos
Autores principales:	You, Yanjie, Wang, Qiang, Li, Haijun, Ma, Yuhong, Deng, Yanhong, Ye, Zhengcai, Bai, Feihu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556542/ https://www.ncbi.nlm.nih.gov/pubmed/31239706 http://dx.doi.org/10.2147/OTT.S202516

Ejemplares similares

Attenuated ZHX3 expression serves as a potential biomarker that predicts poor clinical outcomes in breast cancer patients
por: You, Yanjie, et al.
Publicado: (2019)

Mosloflavone-Resveratrol Hybrid TMS-HDMF-5z Exhibits Potent In Vitro and In Vivo Anti-Inflammatory Effects Through NF-κB, AP-1, and JAK/STAT Inactivation
por: Kim, Seo-Yeon, et al.
Publicado: (2022)

IL-32γ inhibits cancer cell growth through inactivation of NF-κB and STAT3 signals
por: Oh, J H, et al.
Publicado: (2011)

Antitumor activity of IL-32β through the activation of lymphocytes, and the inactivation of NF-κB and STAT3 signals
por: Yun, H-M, et al.
Publicado: (2013)

Papaver nudicaule (Iceland poppy) alleviates lipopolysaccharide-induced inflammation through inactivating NF-κB and STAT3
por: Oh, Jae-Hyeon, et al.
Publicado: (2019)

Zoledronic acid inhibits osteoclast differentiation and function through the regulation of NF-κB and JNK signalling pathways
por: Huang, Xiao-Lin, et al.
Publicado: (2019)

Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling
por: Wu, Xiaoqing, et al.
Publicado: (2016)

Scaffold compound L971 exhibits anti‐inflammatory activities through inhibition of JAK/STAT and NFκB signalling pathways
por: Li, Mengyuan, et al.
Publicado: (2021)

Docoxahexaenoic Acid Induces Apoptosis of Pancreatic Cancer Cells by Suppressing Activation of STAT3 and NF-κB
por: Park, Mirae, et al.
Publicado: (2018)

NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699
por: Hunter, Jill E., et al.
Publicado: (2011)

Stat3 Inhibitor Stattic Exhibits Potent Antitumor Activity and Induces Chemo- and Radio-Sensitivity in Nasopharyngeal Carcinoma
por: Pan, Yunbao, et al.
Publicado: (2013)

Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation
por: Xu, Xuefen, et al.
Publicado: (2017)

STAT3/NF-κB decoy oligodeoxynucleotides inhibit atherosclerosis through regulation of the STAT/NF-κB signaling pathway in a mouse model of atherosclerosis
por: An, Hyun-Jin, et al.
Publicado: (2023)

miR-1266 Contributes to Pancreatic Cancer Progression and Chemoresistance by the STAT3 and NF-κB Signaling Pathways
por: Zhang, Xin, et al.
Publicado: (2018)

lncRNA-XLOC_012370 Promotes the Development of Pancreatic Cancer and Inactivates the NF-κB Pathway Through miR-140-5p
por: Nie, Han-Xiao, et al.
Publicado: (2021)

Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation
por: Platanitis, Ekaterini, et al.
Publicado: (2018)

Correction: Stat3 inhibitor stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma
por: Pan, Yunbao, et al.
Publicado: (2020)

Zoledronic acid inhibits osteoclastogenesis and bone resorptive function by suppressing RANKL-mediated NF-κB and JNK and their downstream signalling pathways
por: Huang, Xiao-Lin, et al.
Publicado: (2022)

Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling
por: De Franceschi, Nicola, et al.
Publicado: (2015)

Emodin Ameliorates LPS-Induced Acute Lung Injury, Involving the Inactivation of NF-κB in Mice
por: Xiao, Min, et al.
Publicado: (2014)

A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-κB inactivation in colorectal cancer cells
por: Chung, Seyung S., et al.
Publicado: (2019)

Author Correction: Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/ NF-κB inactivation
por: Xu, Xuefen, et al.
Publicado: (2021)

Retraction Note: Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation
por: Xu, Xuefen, et al.
Publicado: (2022)

Xanthatin inhibits STAT3 and NF‐κB signalling by covalently binding to JAK and IKK kinases
por: Liu, Man, et al.
Publicado: (2019)

Critical role of NF-κB in pancreatic cancer
por: Prabhu, Lakshmi, et al.
Publicado: (2014)

NF-κB and Pancreatic Cancer; Chapter and Verse
por: Silke, John, et al.
Publicado: (2021)

Zoledronic Acid Sensitizes Renal Cell Carcinoma Cells to Radiation by Downregulating STAT1
por: Kijima, Toshiki, et al.
Publicado: (2013)

Sulfated Chitosan Oligosaccharides Suppress LPS-Induced NO Production via JNK and NF-κB Inactivation
por: Kim, Jung-Hyun, et al.
Publicado: (2014)

Ovatodiolide of Anisomeles indica Exerts the Anticancer Potential on Pancreatic Cancer Cell Lines through STAT3 and NF-κB Regulation
por: Hsieh, Ya-Ju, et al.
Publicado: (2016)

In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells
por: Duan, JingJing, et al.
Publicado: (2016)

Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway
por: Luo, Weixu, et al.
Publicado: (2020)

PHLPP2 suppresses the NF-κB pathway by inactivating IKKβ kinase
por: Agarwal, Nitin Kumar, et al.
Publicado: (2014)

Ionizing radiation-induced NF-κB activation requires PARP-1 function to confer radio-resistance
por: Veuger, Stephany J., et al.
Publicado: (2008)

Salidroside ameliorates severe acute pancreatitis-induced cell injury and pyroptosis by inactivating Akt/NF-κB and caspase-3/GSDME pathways
por: Wang, Xiaohong, et al.
Publicado: (2023)

STAT3 and NF-κB are Simultaneously Suppressed in Dendritic Cells in Lung Cancer
por: Li, Rui, et al.
Publicado: (2017)

Maslinic Acid Ameliorates Inflammation via the Downregulation of NF-κB and STAT-1
por: Lee, Wonhwa, et al.
Publicado: (2020)

Lactobacillus acidophilus ameliorates H. pylori-induced gastric inflammation by inactivating the Smad7 and NFκB pathways
por: Yang, Yao-Jong, et al.
Publicado: (2012)

Glucolipotoxicity initiates pancreatic β-cell death through TNFR5/CD40-mediated STAT1 and NF-κB activation
por: Bagnati, Marta, et al.
Publicado: (2016)

NF-κB Dependent Chemokine Signaling in Pancreatic Cancer
por: Geismann, Claudia, et al.
Publicado: (2019)

Amelioration of Experimental Autoimmune Encephalomyelitis by Plumbagin through Down-Regulation of JAK-STAT and NF-κB Signaling Pathways
por: Jia, Yan, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_t7goo7j8rgm9uk3e9cp7gbk3ak