Decreased expression of MUC2 due to a decrease in the expression of lectins and apoptotic defects in colitis patients

INTRODUCTION: The involvement of mucin, lectin, and apoptosis in colitis is still unclear. This study aimed to investigate changes in MUC2 expression, inflammation, and changes in lectin expression in colitis patients. METHODS: A total of 17 patients were divided into two groups including 11 hemorrh...

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Detalles Bibliográficos
Autores principales: Wibowo, Agung A., Pardjianto, Bambang, Sumitro, Sutiman B., Kania, Nia, Handono, Kusworini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556545/
https://www.ncbi.nlm.nih.gov/pubmed/31198858
http://dx.doi.org/10.1016/j.bbrep.2019.100655
Descripción
Sumario:INTRODUCTION: The involvement of mucin, lectin, and apoptosis in colitis is still unclear. This study aimed to investigate changes in MUC2 expression, inflammation, and changes in lectin expression in colitis patients. METHODS: A total of 17 patients were divided into two groups including 11 hemorrhoid patients as a control group and 6 colitis patients. MUC2 mutation analysis was carried out using immunofluorescent and FISH techniques. Assessment of caspase-3, Ki-67, NF-kB, and lectin expressions was also carried out by immunofluorescent technique then analyzed by confocal laser scanning microscope. RESULTS: The MUC2, caspase-3, and lectin expressions were significantly lower in the colitis group than in the control group (p < 0.05). CONCLUSIONS: It was concluded that in colitis there was a change in MUC2 expression due to changes in lectins accompanied by apoptotic defects.conclusion

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