Cargando…
Challenges in Managing Patients with Hereditary Cancer at Gynecological Services
AIM: To reveal current problems and challenges faced by our gynecologic services department in managing patients with hereditary cancers. METHODS: We collected clinical data of patients with hereditary cancers, identified via genetic testing (or clinically diagnosed in cases of Cowden syndrome or Pe...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556775/ https://www.ncbi.nlm.nih.gov/pubmed/31263500 http://dx.doi.org/10.1155/2019/4365754 |
_version_ | 1783425363014057984 |
---|---|
author | Ueda, Mako Tsubamoto, Hiroshi Kashima-Morii, Mina Torii, Yoshitaka Kamihigashi, Mariko Wakimoto, Yu Nakagomi, Nami Hashimoto-Tamaoki, Tomoko Sawai, Hideaki Shibahara, Hiroaki |
author_facet | Ueda, Mako Tsubamoto, Hiroshi Kashima-Morii, Mina Torii, Yoshitaka Kamihigashi, Mariko Wakimoto, Yu Nakagomi, Nami Hashimoto-Tamaoki, Tomoko Sawai, Hideaki Shibahara, Hiroaki |
author_sort | Ueda, Mako |
collection | PubMed |
description | AIM: To reveal current problems and challenges faced by our gynecologic services department in managing patients with hereditary cancers. METHODS: We collected clinical data of patients with hereditary cancers, identified via genetic testing (or clinically diagnosed in cases of Cowden syndrome or Peutz–Jeghers syndrome), and treated in our gynecological department from 2012 to 2018. RESULTS: Fifteen patients had hereditary breast and ovarian cancer (HBOC), 6 had Lynch syndrome, 2 had Cowden syndrome, and 2 had Peutz–Jeghers syndrome. Five patients diagnosed with HBOC were younger than 40 years at diagnosis. Risk-reducing salpingo-oophorectomy (RRSO) was performed on 1 patient with a BRCA1 mutation at age 38 years. Seven patients overall underwent RRSO, and none had malignancies on pathological examinations. Peritoneal washing cytology (PWC) was suspicious for malignancy in one patient; however, subsequent PWC at 6 months after RRSO was negative. A patient with endometrial cancer and Lynch syndrome and a patient with atypical endometrial hyperplasia (AEH) and Cowden syndrome strongly desired fertility preservation. They achieved remission after medroxyprogesterone acetate treatment and multiple dilations and curettages, respectively. One patient with Lynch syndrome developed AEH after 11 years of surveillance. Laparotomy revealed adjacent low-grade and high-grade serous ovarian cancer with positive ascites cytology. She had no recurrence during 7-year follow-up after laparotomy. CONCLUSION: Managing patients with hereditary cancer, positive or false-positive ascites cytology discovered during RRSO, and desired preservation of fertility is highly challenging. |
format | Online Article Text |
id | pubmed-6556775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65567752019-07-01 Challenges in Managing Patients with Hereditary Cancer at Gynecological Services Ueda, Mako Tsubamoto, Hiroshi Kashima-Morii, Mina Torii, Yoshitaka Kamihigashi, Mariko Wakimoto, Yu Nakagomi, Nami Hashimoto-Tamaoki, Tomoko Sawai, Hideaki Shibahara, Hiroaki Obstet Gynecol Int Research Article AIM: To reveal current problems and challenges faced by our gynecologic services department in managing patients with hereditary cancers. METHODS: We collected clinical data of patients with hereditary cancers, identified via genetic testing (or clinically diagnosed in cases of Cowden syndrome or Peutz–Jeghers syndrome), and treated in our gynecological department from 2012 to 2018. RESULTS: Fifteen patients had hereditary breast and ovarian cancer (HBOC), 6 had Lynch syndrome, 2 had Cowden syndrome, and 2 had Peutz–Jeghers syndrome. Five patients diagnosed with HBOC were younger than 40 years at diagnosis. Risk-reducing salpingo-oophorectomy (RRSO) was performed on 1 patient with a BRCA1 mutation at age 38 years. Seven patients overall underwent RRSO, and none had malignancies on pathological examinations. Peritoneal washing cytology (PWC) was suspicious for malignancy in one patient; however, subsequent PWC at 6 months after RRSO was negative. A patient with endometrial cancer and Lynch syndrome and a patient with atypical endometrial hyperplasia (AEH) and Cowden syndrome strongly desired fertility preservation. They achieved remission after medroxyprogesterone acetate treatment and multiple dilations and curettages, respectively. One patient with Lynch syndrome developed AEH after 11 years of surveillance. Laparotomy revealed adjacent low-grade and high-grade serous ovarian cancer with positive ascites cytology. She had no recurrence during 7-year follow-up after laparotomy. CONCLUSION: Managing patients with hereditary cancer, positive or false-positive ascites cytology discovered during RRSO, and desired preservation of fertility is highly challenging. Hindawi 2019-05-27 /pmc/articles/PMC6556775/ /pubmed/31263500 http://dx.doi.org/10.1155/2019/4365754 Text en Copyright © 2019 Mako Ueda et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ueda, Mako Tsubamoto, Hiroshi Kashima-Morii, Mina Torii, Yoshitaka Kamihigashi, Mariko Wakimoto, Yu Nakagomi, Nami Hashimoto-Tamaoki, Tomoko Sawai, Hideaki Shibahara, Hiroaki Challenges in Managing Patients with Hereditary Cancer at Gynecological Services |
title | Challenges in Managing Patients with Hereditary Cancer at Gynecological Services |
title_full | Challenges in Managing Patients with Hereditary Cancer at Gynecological Services |
title_fullStr | Challenges in Managing Patients with Hereditary Cancer at Gynecological Services |
title_full_unstemmed | Challenges in Managing Patients with Hereditary Cancer at Gynecological Services |
title_short | Challenges in Managing Patients with Hereditary Cancer at Gynecological Services |
title_sort | challenges in managing patients with hereditary cancer at gynecological services |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556775/ https://www.ncbi.nlm.nih.gov/pubmed/31263500 http://dx.doi.org/10.1155/2019/4365754 |
work_keys_str_mv | AT uedamako challengesinmanagingpatientswithhereditarycanceratgynecologicalservices AT tsubamotohiroshi challengesinmanagingpatientswithhereditarycanceratgynecologicalservices AT kashimamoriimina challengesinmanagingpatientswithhereditarycanceratgynecologicalservices AT toriiyoshitaka challengesinmanagingpatientswithhereditarycanceratgynecologicalservices AT kamihigashimariko challengesinmanagingpatientswithhereditarycanceratgynecologicalservices AT wakimotoyu challengesinmanagingpatientswithhereditarycanceratgynecologicalservices AT nakagominami challengesinmanagingpatientswithhereditarycanceratgynecologicalservices AT hashimototamaokitomoko challengesinmanagingpatientswithhereditarycanceratgynecologicalservices AT sawaihideaki challengesinmanagingpatientswithhereditarycanceratgynecologicalservices AT shibaharahiroaki challengesinmanagingpatientswithhereditarycanceratgynecologicalservices |