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Probiotics for Alleviating Alcoholic Liver Injury
Many animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. Alcohol disrupts the composition of intestinal flora; probiotics modulate the gut microbiota and reverse alcohol-associated intestinal barrier dysfunction by decreasing inte...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556793/ https://www.ncbi.nlm.nih.gov/pubmed/31263495 http://dx.doi.org/10.1155/2019/9097276 |
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author | Gu, Zelin Liu, Yanlong Hu, Shumeng You, Ying Wen, Jiaqi Li, Wancong Wang, Yuhua |
author_facet | Gu, Zelin Liu, Yanlong Hu, Shumeng You, Ying Wen, Jiaqi Li, Wancong Wang, Yuhua |
author_sort | Gu, Zelin |
collection | PubMed |
description | Many animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. Alcohol disrupts the composition of intestinal flora; probiotics modulate the gut microbiota and reverse alcohol-associated intestinal barrier dysfunction by decreasing intestinal mucosal permeability and preventing intestinal bacteria from translocating. Probiotics enhance immune responses and reduce the levels of alcohol-induced inflammatory cytokines and reactive oxygen species (ROS) production in the liver and intestine. Probiotics also increase fatty acid β-oxidation and reduce lipogenesis, combating alcohol-induced hepatic steatosis. In this review, we summarize the current knowledge regarding the mechanism of action of probiotics for reducing the effects of alcoholic liver disease. |
format | Online Article Text |
id | pubmed-6556793 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65567932019-07-01 Probiotics for Alleviating Alcoholic Liver Injury Gu, Zelin Liu, Yanlong Hu, Shumeng You, Ying Wen, Jiaqi Li, Wancong Wang, Yuhua Gastroenterol Res Pract Review Article Many animal experiments and clinical trials showed that probiotics are effective for the treatment of alcoholic liver disease. Alcohol disrupts the composition of intestinal flora; probiotics modulate the gut microbiota and reverse alcohol-associated intestinal barrier dysfunction by decreasing intestinal mucosal permeability and preventing intestinal bacteria from translocating. Probiotics enhance immune responses and reduce the levels of alcohol-induced inflammatory cytokines and reactive oxygen species (ROS) production in the liver and intestine. Probiotics also increase fatty acid β-oxidation and reduce lipogenesis, combating alcohol-induced hepatic steatosis. In this review, we summarize the current knowledge regarding the mechanism of action of probiotics for reducing the effects of alcoholic liver disease. Hindawi 2019-05-27 /pmc/articles/PMC6556793/ /pubmed/31263495 http://dx.doi.org/10.1155/2019/9097276 Text en Copyright © 2019 Zelin Gu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gu, Zelin Liu, Yanlong Hu, Shumeng You, Ying Wen, Jiaqi Li, Wancong Wang, Yuhua Probiotics for Alleviating Alcoholic Liver Injury |
title | Probiotics for Alleviating Alcoholic Liver Injury |
title_full | Probiotics for Alleviating Alcoholic Liver Injury |
title_fullStr | Probiotics for Alleviating Alcoholic Liver Injury |
title_full_unstemmed | Probiotics for Alleviating Alcoholic Liver Injury |
title_short | Probiotics for Alleviating Alcoholic Liver Injury |
title_sort | probiotics for alleviating alcoholic liver injury |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556793/ https://www.ncbi.nlm.nih.gov/pubmed/31263495 http://dx.doi.org/10.1155/2019/9097276 |
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