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Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin

Daptomycin (DAP), a cyclic lipopeptide produced by Streptomyces roseosporus, is a novel antibiotic to clinically treat various Gram-positive pathogenic bacteria-induced infections. Although DAP has a strong broad-spectrum bactericidal effect, recently rare bacterial antibiotic resistance against DAP...

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Detalles Bibliográficos
Autores principales: Ye, Yang, Xia, Zijing, Zhang, Dan, Sheng, Zenghua, Zhang, Peng, Zhu, Hongxia, Xu, Ningzhi, Liang, Shufang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556800/
https://www.ncbi.nlm.nih.gov/pubmed/31263709
http://dx.doi.org/10.1155/2019/8609218
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author Ye, Yang
Xia, Zijing
Zhang, Dan
Sheng, Zenghua
Zhang, Peng
Zhu, Hongxia
Xu, Ningzhi
Liang, Shufang
author_facet Ye, Yang
Xia, Zijing
Zhang, Dan
Sheng, Zenghua
Zhang, Peng
Zhu, Hongxia
Xu, Ningzhi
Liang, Shufang
author_sort Ye, Yang
collection PubMed
description Daptomycin (DAP), a cyclic lipopeptide produced by Streptomyces roseosporus, is a novel antibiotic to clinically treat various Gram-positive pathogenic bacteria-induced infections. Although DAP has a strong broad-spectrum bactericidal effect, recently rare bacterial antibiotic resistance against DAP gradually arises. The review is to summarize the normal indications of DAP, its off-label usage against several clinical pathogen infections, the unique antibacterial mechanisms of DAP, and the combination of antibiotic therapies for highly DAP-resistant pathogens. More noticeably, rising evidences demonstrate that DAP has new potential activity of anticancer and immunomodulatory effects. So far the multifunctional pharmaceutical effects of DAP deserve to be further explored for future clinical applications.
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spelling pubmed-65568002019-07-01 Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin Ye, Yang Xia, Zijing Zhang, Dan Sheng, Zenghua Zhang, Peng Zhu, Hongxia Xu, Ningzhi Liang, Shufang Biomed Res Int Review Article Daptomycin (DAP), a cyclic lipopeptide produced by Streptomyces roseosporus, is a novel antibiotic to clinically treat various Gram-positive pathogenic bacteria-induced infections. Although DAP has a strong broad-spectrum bactericidal effect, recently rare bacterial antibiotic resistance against DAP gradually arises. The review is to summarize the normal indications of DAP, its off-label usage against several clinical pathogen infections, the unique antibacterial mechanisms of DAP, and the combination of antibiotic therapies for highly DAP-resistant pathogens. More noticeably, rising evidences demonstrate that DAP has new potential activity of anticancer and immunomodulatory effects. So far the multifunctional pharmaceutical effects of DAP deserve to be further explored for future clinical applications. Hindawi 2019-05-27 /pmc/articles/PMC6556800/ /pubmed/31263709 http://dx.doi.org/10.1155/2019/8609218 Text en Copyright © 2019 Yang Ye et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ye, Yang
Xia, Zijing
Zhang, Dan
Sheng, Zenghua
Zhang, Peng
Zhu, Hongxia
Xu, Ningzhi
Liang, Shufang
Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin
title Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin
title_full Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin
title_fullStr Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin
title_full_unstemmed Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin
title_short Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin
title_sort multifunctional pharmaceutical effects of the antibiotic daptomycin
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556800/
https://www.ncbi.nlm.nih.gov/pubmed/31263709
http://dx.doi.org/10.1155/2019/8609218
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