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Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin
Daptomycin (DAP), a cyclic lipopeptide produced by Streptomyces roseosporus, is a novel antibiotic to clinically treat various Gram-positive pathogenic bacteria-induced infections. Although DAP has a strong broad-spectrum bactericidal effect, recently rare bacterial antibiotic resistance against DAP...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556800/ https://www.ncbi.nlm.nih.gov/pubmed/31263709 http://dx.doi.org/10.1155/2019/8609218 |
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author | Ye, Yang Xia, Zijing Zhang, Dan Sheng, Zenghua Zhang, Peng Zhu, Hongxia Xu, Ningzhi Liang, Shufang |
author_facet | Ye, Yang Xia, Zijing Zhang, Dan Sheng, Zenghua Zhang, Peng Zhu, Hongxia Xu, Ningzhi Liang, Shufang |
author_sort | Ye, Yang |
collection | PubMed |
description | Daptomycin (DAP), a cyclic lipopeptide produced by Streptomyces roseosporus, is a novel antibiotic to clinically treat various Gram-positive pathogenic bacteria-induced infections. Although DAP has a strong broad-spectrum bactericidal effect, recently rare bacterial antibiotic resistance against DAP gradually arises. The review is to summarize the normal indications of DAP, its off-label usage against several clinical pathogen infections, the unique antibacterial mechanisms of DAP, and the combination of antibiotic therapies for highly DAP-resistant pathogens. More noticeably, rising evidences demonstrate that DAP has new potential activity of anticancer and immunomodulatory effects. So far the multifunctional pharmaceutical effects of DAP deserve to be further explored for future clinical applications. |
format | Online Article Text |
id | pubmed-6556800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-65568002019-07-01 Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin Ye, Yang Xia, Zijing Zhang, Dan Sheng, Zenghua Zhang, Peng Zhu, Hongxia Xu, Ningzhi Liang, Shufang Biomed Res Int Review Article Daptomycin (DAP), a cyclic lipopeptide produced by Streptomyces roseosporus, is a novel antibiotic to clinically treat various Gram-positive pathogenic bacteria-induced infections. Although DAP has a strong broad-spectrum bactericidal effect, recently rare bacterial antibiotic resistance against DAP gradually arises. The review is to summarize the normal indications of DAP, its off-label usage against several clinical pathogen infections, the unique antibacterial mechanisms of DAP, and the combination of antibiotic therapies for highly DAP-resistant pathogens. More noticeably, rising evidences demonstrate that DAP has new potential activity of anticancer and immunomodulatory effects. So far the multifunctional pharmaceutical effects of DAP deserve to be further explored for future clinical applications. Hindawi 2019-05-27 /pmc/articles/PMC6556800/ /pubmed/31263709 http://dx.doi.org/10.1155/2019/8609218 Text en Copyright © 2019 Yang Ye et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ye, Yang Xia, Zijing Zhang, Dan Sheng, Zenghua Zhang, Peng Zhu, Hongxia Xu, Ningzhi Liang, Shufang Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin |
title | Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin |
title_full | Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin |
title_fullStr | Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin |
title_full_unstemmed | Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin |
title_short | Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin |
title_sort | multifunctional pharmaceutical effects of the antibiotic daptomycin |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556800/ https://www.ncbi.nlm.nih.gov/pubmed/31263709 http://dx.doi.org/10.1155/2019/8609218 |
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