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Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis
Researchers have used dogs with neurological sequelae caused by distemper as an experimental model for multiple sclerosis, owing to the similarities of the neuropathological changes between distemper virus-induced demyelinating leukoencephalitis and multiple sclerosis in humans. However, little is k...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556833/ https://www.ncbi.nlm.nih.gov/pubmed/31198874 http://dx.doi.org/10.1016/j.heliyon.2019.e01857 |
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author | Pinheiro, Luane Lopes de Lima, Ana Rita Martins, Danielli Martinelli de Oliveira, Edivaldo Herculano C. Souza, Michel Platini C. de Carvalho Miranda, Carla Maria Figueiredo Baleeiro Beltrão-Braga, Patrícia Cristina Russo, Fabiele Baldino Pignatari, Graciela Conceição da Silva Filho, Ednaldo Branco, Érika |
author_facet | Pinheiro, Luane Lopes de Lima, Ana Rita Martins, Danielli Martinelli de Oliveira, Edivaldo Herculano C. Souza, Michel Platini C. de Carvalho Miranda, Carla Maria Figueiredo Baleeiro Beltrão-Braga, Patrícia Cristina Russo, Fabiele Baldino Pignatari, Graciela Conceição da Silva Filho, Ednaldo Branco, Érika |
author_sort | Pinheiro, Luane Lopes |
collection | PubMed |
description | Researchers have used dogs with neurological sequelae caused by distemper as an experimental model for multiple sclerosis, owing to the similarities of the neuropathological changes between distemper virus-induced demyelinating leukoencephalitis and multiple sclerosis in humans. However, little is known about the role of mesenchymal stem cells in treating such clinical conditions. Therefore, we investigated the use of mesenchymal stem cells in four dogs with neurological lesions caused by the distemper virus. During the first year after cellular therapy, the animals did not demonstrate significant changes in their locomotive abilities. However, the intense (Grade V) myoclonus in three animals was reduced to a moderate (Grade IV) level. At one year after the mesenchymal stem cell infusions, three animals regained functional ambulation (Grade I), and all four dogs started to move independently (Grades I and II). In two animals, the myoclonic severity had become mild (Grade III). It was concluded that the use of mesenchymal stem cells could improve the quality of life of dogs with neurological sequelae caused by canine distemper, thus presenting hope for similar positive results in human patients with multiple sclerosis. |
format | Online Article Text |
id | pubmed-6556833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-65568332019-06-13 Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis Pinheiro, Luane Lopes de Lima, Ana Rita Martins, Danielli Martinelli de Oliveira, Edivaldo Herculano C. Souza, Michel Platini C. de Carvalho Miranda, Carla Maria Figueiredo Baleeiro Beltrão-Braga, Patrícia Cristina Russo, Fabiele Baldino Pignatari, Graciela Conceição da Silva Filho, Ednaldo Branco, Érika Heliyon Article Researchers have used dogs with neurological sequelae caused by distemper as an experimental model for multiple sclerosis, owing to the similarities of the neuropathological changes between distemper virus-induced demyelinating leukoencephalitis and multiple sclerosis in humans. However, little is known about the role of mesenchymal stem cells in treating such clinical conditions. Therefore, we investigated the use of mesenchymal stem cells in four dogs with neurological lesions caused by the distemper virus. During the first year after cellular therapy, the animals did not demonstrate significant changes in their locomotive abilities. However, the intense (Grade V) myoclonus in three animals was reduced to a moderate (Grade IV) level. At one year after the mesenchymal stem cell infusions, three animals regained functional ambulation (Grade I), and all four dogs started to move independently (Grades I and II). In two animals, the myoclonic severity had become mild (Grade III). It was concluded that the use of mesenchymal stem cells could improve the quality of life of dogs with neurological sequelae caused by canine distemper, thus presenting hope for similar positive results in human patients with multiple sclerosis. Elsevier 2019-06-08 /pmc/articles/PMC6556833/ /pubmed/31198874 http://dx.doi.org/10.1016/j.heliyon.2019.e01857 Text en © 2019 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Pinheiro, Luane Lopes de Lima, Ana Rita Martins, Danielli Martinelli de Oliveira, Edivaldo Herculano C. Souza, Michel Platini C. de Carvalho Miranda, Carla Maria Figueiredo Baleeiro Beltrão-Braga, Patrícia Cristina Russo, Fabiele Baldino Pignatari, Graciela Conceição da Silva Filho, Ednaldo Branco, Érika Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
title | Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
title_full | Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
title_fullStr | Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
title_full_unstemmed | Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
title_short | Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
title_sort | mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556833/ https://www.ncbi.nlm.nih.gov/pubmed/31198874 http://dx.doi.org/10.1016/j.heliyon.2019.e01857 |
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