Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1 mutant mice

Fragile X syndrome results from a loss of the RNA-binding protein fragile X mental retardation protein (FMRP). How FMRP regulates neuronal development and function remains unclear. Here, we show that FMRP-deficient immature neurons exhibit impaired dendritic maturation, altered expression of mitocho...

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Detalles Bibliográficos
Autores principales: Shen, Minjie, Wang, Feifei, Li, Meng, Sah, Nirnath, Stockton, Michael E., Tidei, Joseph J., Gao, Yu, Korabelnikov, Tomer, Kannan, Sudharsan, Vevea, Jason D., Chapman, Edwin R., Bhattacharyya, Anita, van Praag, Henriette, Zhao, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556892/
https://www.ncbi.nlm.nih.gov/pubmed/30742117
http://dx.doi.org/10.1038/s41593-019-0338-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556892/
https://www.ncbi.nlm.nih.gov/pubmed/30742117
http://dx.doi.org/10.1038/s41593-019-0338-y

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