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Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study

The cingulum, connecting the orbitofrontal cortex to the medial temporal lobe, involves in diverse cognition functions including attention, memory, and motivation. To investigate the relationship between the cingulum injury and cognitive impairment in patients with chronic mild traumatic brain injur...

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Autores principales: Jang, Sung Ho, Kim, Seong Ho, Lee, Han Do
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557111/
https://www.ncbi.nlm.nih.gov/pubmed/31089054
http://dx.doi.org/10.4103/1673-5374.255977
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author Jang, Sung Ho
Kim, Seong Ho
Lee, Han Do
author_facet Jang, Sung Ho
Kim, Seong Ho
Lee, Han Do
author_sort Jang, Sung Ho
collection PubMed
description The cingulum, connecting the orbitofrontal cortex to the medial temporal lobe, involves in diverse cognition functions including attention, memory, and motivation. To investigate the relationship between the cingulum injury and cognitive impairment in patients with chronic mild traumatic brain injury, we evaluated the integrity between the anterior cingulum and the basal forebrain using diffusion tensor tractography in 73 patients with chronic mild traumatic brain injury (39 males, 34 females, age 43.29 ± 11.42 years) and 40 healthy controls (22 males, 18 females, age 40.11 ± 16.81 years). The patients were divided into three subgroups based on the integrity between the anterior cingulum and the basal forebrain on diffusion tensor tractography: subgroup A (n = 19 patients) – both sides of the anterior cingulum were intact; subgroup B (n = 36 patients) – either side of the anterior cingulum was intact; and subgroup C (18 patients) – both sides of the anterior cingulum were discontinued. There were significant differences in total Memory Assessment Scale score between subgroups A and B and between subgroups A and C. There were no significant differences in diffusion tensor tractography parameters (fractional anisotropy, apparent diffusion coefficient, and fiber volume) between patients and controls. These findings suggest that the integrity between the anterior cingulum and the basal forebrain, but not diffusion tensor tractography parameter, can be used to predict the cognitive function of patients with chronic mild traumatic brain injury. This study was approved by Yeungnam University Hospital Institutional Review Board (approval No. YUMC-2014-01-425-010) on August 16, 2017.
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spelling pubmed-65571112019-09-01 Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study Jang, Sung Ho Kim, Seong Ho Lee, Han Do Neural Regen Res Research Article The cingulum, connecting the orbitofrontal cortex to the medial temporal lobe, involves in diverse cognition functions including attention, memory, and motivation. To investigate the relationship between the cingulum injury and cognitive impairment in patients with chronic mild traumatic brain injury, we evaluated the integrity between the anterior cingulum and the basal forebrain using diffusion tensor tractography in 73 patients with chronic mild traumatic brain injury (39 males, 34 females, age 43.29 ± 11.42 years) and 40 healthy controls (22 males, 18 females, age 40.11 ± 16.81 years). The patients were divided into three subgroups based on the integrity between the anterior cingulum and the basal forebrain on diffusion tensor tractography: subgroup A (n = 19 patients) – both sides of the anterior cingulum were intact; subgroup B (n = 36 patients) – either side of the anterior cingulum was intact; and subgroup C (18 patients) – both sides of the anterior cingulum were discontinued. There were significant differences in total Memory Assessment Scale score between subgroups A and B and between subgroups A and C. There were no significant differences in diffusion tensor tractography parameters (fractional anisotropy, apparent diffusion coefficient, and fiber volume) between patients and controls. These findings suggest that the integrity between the anterior cingulum and the basal forebrain, but not diffusion tensor tractography parameter, can be used to predict the cognitive function of patients with chronic mild traumatic brain injury. This study was approved by Yeungnam University Hospital Institutional Review Board (approval No. YUMC-2014-01-425-010) on August 16, 2017. Wolters Kluwer - Medknow 2019-09 /pmc/articles/PMC6557111/ /pubmed/31089054 http://dx.doi.org/10.4103/1673-5374.255977 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Research Article
Jang, Sung Ho
Kim, Seong Ho
Lee, Han Do
Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study
title Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study
title_full Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study
title_fullStr Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study
title_full_unstemmed Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study
title_short Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study
title_sort traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557111/
https://www.ncbi.nlm.nih.gov/pubmed/31089054
http://dx.doi.org/10.4103/1673-5374.255977
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