Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3

Chemical modifications of histones can mediate diverse DNA-templated processes including gene transcription(1–3). Here, we provide evidence for a new class of histone posttranslational modification (PTM), serotonylation of glutamine, which occurs at position 5 (Q5ser) on histone H3 in serotonin (5-h...

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Detalles Bibliográficos
Autores principales: Farrelly, Lorna A., Thompson, Robert E., Zhao, Shuai, Lepack, Ashley E., Lyu, Yang, Bhanu, Natarajan V., Zhang, Baichao, Loh, Yong-Hwee E., Ramakrishnan, Aarthi, Vadodaria, Krishna C., Heard, Kelly J., Erikson, Galina, Nakadai, Tomoyoshi, Bastle, Ryan M., Lukasak, Bradley J., Zebroski, Henry, Alenina, Natalia, Bader, Michael, Berton, Olivier, Roeder, Robert G., Molina, Henrik, Gage, Fred H., Shen, Li, Garcia, Benjamin A., Li, Haitao, Muir, Tom W., Maze, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557285/
https://www.ncbi.nlm.nih.gov/pubmed/30867594
http://dx.doi.org/10.1038/s41586-019-1024-7

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