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Hispanic representation in diabetes cardiovascular outcomes trials

OBJECTIVE: To examine Hispanic/Latino representation in diabetes cardiovascular outcomes trials for novel antidiabetic drugs. RESEARCH DESIGN AND METHODS: We compared Hispanic/Latino representation, age, gender and body mass index in diabetes cardiovascular outcomes trials published from January 200...

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Autores principales: Kelley, A. Taylor, Mizokami-Stout, Kara, O'Brien, Matthew J., Bowen, Michael E., Sussman, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557465/
https://www.ncbi.nlm.nih.gov/pubmed/31245007
http://dx.doi.org/10.1136/bmjdrc-2019-000656
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author Kelley, A. Taylor
Mizokami-Stout, Kara
O'Brien, Matthew J.
Bowen, Michael E.
Sussman, Jeremy
author_facet Kelley, A. Taylor
Mizokami-Stout, Kara
O'Brien, Matthew J.
Bowen, Michael E.
Sussman, Jeremy
author_sort Kelley, A. Taylor
collection PubMed
description OBJECTIVE: To examine Hispanic/Latino representation in diabetes cardiovascular outcomes trials for novel antidiabetic drugs. RESEARCH DESIGN AND METHODS: We compared Hispanic/Latino representation, age, gender and body mass index in diabetes cardiovascular outcomes trials published from January 2008 to October 2018 to Hispanic adults with diabetes in the National Health Examination and Nutrition Survey over the same time period. RESULTS: Hispanics/Latinos comprised 18.5 % of trial subjects, which was similar to the proportion of US adults with diabetes who identify as Hispanic. Trial subjects were significantly younger, more likely to be female, and more obese than US Hispanics/Latinos. At least 10 different Latin American countries and territories were represented across the 10 trials. CONCLUSIONS: US Hispanics/Latinos differ from subjects in diabetes cardiovascular outcomes trials, which may limit generalizability of trial results.
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spelling pubmed-65574652019-06-26 Hispanic representation in diabetes cardiovascular outcomes trials Kelley, A. Taylor Mizokami-Stout, Kara O'Brien, Matthew J. Bowen, Michael E. Sussman, Jeremy BMJ Open Diabetes Res Care Cardiovascular and Metabolic Risk OBJECTIVE: To examine Hispanic/Latino representation in diabetes cardiovascular outcomes trials for novel antidiabetic drugs. RESEARCH DESIGN AND METHODS: We compared Hispanic/Latino representation, age, gender and body mass index in diabetes cardiovascular outcomes trials published from January 2008 to October 2018 to Hispanic adults with diabetes in the National Health Examination and Nutrition Survey over the same time period. RESULTS: Hispanics/Latinos comprised 18.5 % of trial subjects, which was similar to the proportion of US adults with diabetes who identify as Hispanic. Trial subjects were significantly younger, more likely to be female, and more obese than US Hispanics/Latinos. At least 10 different Latin American countries and territories were represented across the 10 trials. CONCLUSIONS: US Hispanics/Latinos differ from subjects in diabetes cardiovascular outcomes trials, which may limit generalizability of trial results. BMJ Publishing Group 2019-05-04 /pmc/articles/PMC6557465/ /pubmed/31245007 http://dx.doi.org/10.1136/bmjdrc-2019-000656 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Cardiovascular and Metabolic Risk
Kelley, A. Taylor
Mizokami-Stout, Kara
O'Brien, Matthew J.
Bowen, Michael E.
Sussman, Jeremy
Hispanic representation in diabetes cardiovascular outcomes trials
title Hispanic representation in diabetes cardiovascular outcomes trials
title_full Hispanic representation in diabetes cardiovascular outcomes trials
title_fullStr Hispanic representation in diabetes cardiovascular outcomes trials
title_full_unstemmed Hispanic representation in diabetes cardiovascular outcomes trials
title_short Hispanic representation in diabetes cardiovascular outcomes trials
title_sort hispanic representation in diabetes cardiovascular outcomes trials
topic Cardiovascular and Metabolic Risk
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557465/
https://www.ncbi.nlm.nih.gov/pubmed/31245007
http://dx.doi.org/10.1136/bmjdrc-2019-000656
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