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Heterogeneity in Mitogen-Activated Protein Kinase (MAPK) Pathway Activation in Uveal Melanoma With Somatic GNAQ and GNA11 Mutations

PURPOSE: The activation of the mitogen-activated protein kinase (MAPK) pathway has been suggested as the major downstream target when GNAQ and GNA11 (GNAQ/11) are mutated in uveal melanoma (UM). However, clinical trials with single agent MEK inhibitor showed no clinical significance in altering the...

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Detalles Bibliográficos
Autores principales:	Boru, Getachew, Cebulla, Colleen M., Sample, Klarke M., Massengill, James B., Davidorf, Frederick H., Abdel-Rahman, Mohamed H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2019
Materias:	Anatomy and Pathology/Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557618/ https://www.ncbi.nlm.nih.gov/pubmed/31173078 http://dx.doi.org/10.1167/iovs.18-26452

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